Manchester City vs Manchester United: Predictions, Betting odds, Lineups, Preview

• Man City tipped to get back to winning ways with a 2-1 victory in the Manchester Derby

• Recent fixtures make this one hard to call, with both sides winning two of the last five Premier League meetings

• Bernardo Silva's flair and creativity will be crucial in breaking down a stubborn Man United defence

Explore Ladbrokes’ detailed preview for Manchester City vs Manchester United in the Premier League. Stats, odds, predictions, and lineups for the 16:30 BST match.

• Fixture: Manchester City vs Manchester United

• Date: Sunday, 14 September 2025

• Kick-off: 16:30 BST

• Venue: Etihad Stadium

Match Prediction: Manchester City 2-1 Manchester United

Manchester City's recent form has been a bit shaky, losing to Brighton and Tottenham, but they did smash Wolves 4-0 away. They'll be looking to bounce back at home, using their attacking flair to break down Man United's defence. United, on the other hand, have been inconsistent, beating Burnley but drawing with Fulham and losing to Arsenal. They'll need to be solid at the back and take their chances if they want to nick a result at the Etihad.

The game could be tight, with City likely to dominate possession and create more chances. However, United have shown they can score at crucial moments, so expect them to be a threat on the counter. It might come down to which team takes their opportunities better on the day.

City's recent form has been a bit up and down, with two losses following a convincing win. The losses to Brighton and Tottenham will be a concern, but the 4-0 thrashing of Wolves shows they can still turn it on. They'll need to be more consistent if they want to get back to winning ways against United. They might need to adjust their midfield setup, but the attacking talent is still there to cause problems.

Recent Premier League Results:

• Loss: 1-2 vs Brighton & Hove Albion (A)

• Loss: 0-2 vs Tottenham Hotspur (H)

• Win: 4-0 vs Wolverhampton Wanderers (A)

United have had mixed results lately, with a win, a draw, and a loss in their last three games. The win against Burnley was good, but the draw with Fulham and the loss to Arsenal show they need to be more consistent. They'll need to be at their best to get a result at the Etihad, especially with Martinez out injured. If they can keep it tight at the back and hit City on the break, they might pull off an upset.

Recent Premier League Results:

• Win: 3-2 vs Burnley (H)

• Draw: 1-1 vs Fulham (A)

• Loss: 0-1 vs Arsenal (H)

Recent history suggests United and City are well matched, with two wins each and one draw in their last five league games. City have scored more goals in these meetings, but in the previous game, neither side found the net.

Recent Premier League Results

• Manchester United 0-0 Manchester City (06 Apr 2025)

• Manchester City 1-2 Manchester United (15 Dec 2024)

• Manchester City 3-1 Manchester United (03 Mar 2024)

• Manchester United 0-3 Manchester City (29 Oct 2023)

• Manchester United 2-1 Manchester City (14 Jan 2023)

• Mateo Kovačić (Achilles Tendon) - Out

• Rayan Cherki (Muscle) - Out

• Marcus Bettinelli (Knock) - Doubt

• Savinho (Knock) - Doubt

• Joško Gvardiol (Knock) - Doubt

• Lisandro Martínez (Cruciate Ligament) - Out

• Matheus Cunha (Hamstring) - Doubt

• Trafford, Nunes, Stones, Khusanov, Aït-Nouri, Silva, Rodri, Reijnders, Bobb, Haaland, Marmoush

With Kovačić out, City will rely on Rodri to anchor the midfield and control the game's tempo. The attacking quartet of Haaland, Silva, Marmoush, and Bobb will be key to breaking down United's defence.

• Bayındır, Yoro, de Ligt, Shaw, Diallo, Casemiro, Fernandes, Dalot, Mbeumo, Mount, Cunha (if fit)

United will look to Fernandes and Casemiro to dictate play in midfield and launch quick counters. The pace of Diallo and Dalot on the wings could be crucial in exploiting any gaps in City's defence.

• Erling Haaland vs Matthijs de Ligt: Haaland's goal-scoring prowess will be tested against de Ligt's defensive solidity.

• Bruno Fernandes vs Rodri: Fernandes' creativity will be crucial for United, but Rodri's midfield control could stifle his influence.

• Bernardo Silva (Manchester City): Silva's ability to unlock defences with his passing and movement could be key for City.

• Luke Shaw (Manchester United): Shaw's defensive work and overlapping runs down the left could be vital for United's chances.

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Odds and market details are accurate as of the time of publication.