Real Madrid vs Manchester City: Predictions, Betting odds, Lineups, Preview

Explore Ladbrokes' detailed preview for Real Madrid vs Manchester City in the UEFA Champions League. Stats, odds, predictions, and lineups for the 20:00 GMT match.

• Fixture: Real Madrid vs Manchester City
• Date: Wednesday, 10 December 2025
• Kick-off: 20:00 GMT
• Venue: Estadio Santiago Bernabéu

Real Madrid come into this match with a strong run of form, having won four out of their last five games. Their recent victory against Olympiakos Piraeus, despite being a close 4-3, shows their resilience and attacking prowess. With key players like Mbappe and Vinicius Junior in the lineup, they are likely to pose a significant threat to Manchester City's defence. However, their loss to Liverpool indicates they can be vulnerable, especially away from home.

Manchester City, on the other hand, have had a mixed bag of results recently, with a notable loss at home to Bayer Leverkusen. Their ability to improve on that with a previous 4-1 win against Borussia Dortmund suggests they can be unpredictable. With Haaland leading the attack and a solid midfield trio of Silva, Reijnders, and González, they have the potential to challenge Real Madrid. Yet, their recent form might make them the underdogs in this encounter.

Real Madrid have been in fine form, securing victories in four of their last five matches. Their most recent win against Olympiakos Piraeus, despite being a nail-biter at 4-3, showcases their ability to come out on top in high-scoring games. The only blemish on their record is a 0-1 loss to Liverpool, but overall, their confidence should be high going into this match.

Recent UEFA Champions League Results:

• Win: 4-3 vs Olympiakos Piraeus (A)
• Loss: 0-1 vs Liverpool (A)
• Win: 1-0 vs Juventus (H)
• Win: 5-0 vs Kairat Almaty (A)
• Win: 2-1 vs Marseille (H)

Manchester City's recent form has been less consistent, with a disappointing 0-2 loss at home to Bayer Leverkusen. However, they managed to precede that with a convincing 4-1 win against Borussia Dortmund, showing their potential to secure victories. Their form suggests they can be unpredictable, which might make them a risky bet but also capable of pulling off a surprise.

Recent UEFA Champions League Results:

• Loss: 0-2 vs Bayer Leverkusen (H)

• Win: 4-1 vs Borussia Dortmund (H)

• Win: 2-0 vs Villarreal (A)

• Draw: 2-2 vs Monaco (A)

• Win: 2-0 vs Napoli (H)

The head-to-head record between Real Madrid and Manchester City has been closely contested recently. Real Madrid have won the last three encounters, including a 3-1 victory in their most recent meeting in February 2025. However, Manchester City did manage a convincing 4-0 win in their earlier clash in May 2023, showing they can be a formidable opponent when at their best.

Recent UEFA Champions League Results

• Real Madrid 3-1 Manchester City (19 Feb 2025)

• Manchester City 2-3 Real Madrid (11 Feb 2025)

• Manchester City 0-0 (a.e.t.) (3-4 pen.) Real Madrid (17 Apr 2024)

• Real Madrid 3-3 Manchester City (09 Apr 2024)

• Manchester City 4-0 Real Madrid (17 May 2023)

• Ferland Mendy (Muscle) - Out

• Dani Carvajal (Knee) - Out

• David Alaba (Muscle) - Doubt

• Dean Huijsen (Muscle) - Doubt

• Mateo Kovacic (Ankle) - Out

• Rodri (Lack of Fitness) - Doubt

• Predicted lineup: Courtois (GK), Alexander-Arnold (DF), Asencio (DF), Rüdiger (DF), Carreras (DF), Camavinga (MF), Tchouameni (MF), Valverde (MF), Guler (MF), Vinicius Junior (MF), Mbappe (AT)

Real Madrid are expected to line up in a 4-2-3-1 formation, with Tchouameni and Camavinga anchoring the midfield. This setup should allow Valverde to push forward and support the attacking trio of Guler, Vinicius Junior, and Mbappe, who will look to exploit any gaps in Manchester City's defence.

• Predicted lineup: Donnarumma (GK), Nunes (DF), Dias (DF), Gvardiol (DF), O'Reilly (DF), Silva (MF), González (MF), Reijnders (MF), Foden (AT), Haaland (AT), Doku (AT)

Manchester City are predicted to use a 4-3-3 formation, with Silva, González, and Reijnders forming a solid midfield trio. This setup should provide a strong foundation for the attacking line of Foden, Doku, and Haaland, who will aim to break through Real Madrid's defence with their pace and creativity.

• Vinicius Junior vs Matheus Nunes: Vinicius Junior's pace and dribbling skills will be tested against Nunes' defensive solidity.

• Federico Valverde vs Bernardo Silva: Valverde's dynamic play will face a stern challenge from Silva's midfield control.

• Arda Guler (Real Madrid): Guler's role in distributing the ball and creating chances will be crucial for Real Madrid.

• Jeremy Doku (Manchester City): Doku's ability to create and score goals will be key for Manchester City's chances.

Real Madrid vs Manchester City at 20:00 GMT on Wednesday, 10 December 2025 is being broadcast live for viewers in the UK on TNT Sports 1

Ladbrokes is predicting that the score will be Real Madrid 3-2 Manchester City in this match

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