NFL London preview: Jacksonville Jaguars vs Philadelphia Eagles odds, betting tips & prediction

The second NFL London game of 2026 takes place on Sunday, October 11, as the Jacksonville Jaguars face the Philadelphia Eagles.

Ladbrokes' latest Jaguars vs Eagles odds have Jacksonville as 7.5-point favourites on the spread, with the points total set at 41.5. Kick-off is at 2.30pm UK time.

The Jaguars embark on their annual trip to London looking like one of the NFL's elite teams through the first month of the season. An impressive 22-17 win on the road in Cincinnati moved them to 3-1, and Jacksonville have plenty of balance in all phases. Quarterback Trevor Lawrence is playing assured football, backed by a solid run game and a defense that excels at forcing turnovers.

Running back tandem Bhayshul Tuten and Chris Rodriguez each have two rushing touchdowns, while the receiving corps of Parker Washington, Brian Thomas Jr and Jakobi Meyers provide threats in all phases, with tight end Brenton Strange another reliable pass catcher. Two-way star Travis Hunter looks to be growing into his role at cornerback, which would elevate the defense yet another level.

Jacksonville are 7-7 all time in international games, with all of them taking place in London.

The Eagles are dealing with a litany of injuries and are likely to be without two of their key offensive players in running back Saquon Barkley and wide receiver Devonta Smith. The absence of Smith is more pronounced after trading away AJ Brown, while to make matters worse Dontayvion Wicks has been dealing with a hamstring injury this week. Tight end Dallas Goedert has also missed time, but could return this week.

Philadelphia is reeling after back-to-back losses, throwing away a double-digit fourth quarter lead against the LA Rams last week to lose 24-20. The offense struggled, with Jalen Hurts passing for fewer than 100 yards, after a poor performance the week before in a 27-7 defeat in Chicago. Lynchpin right tackle Lane Johnson announced his shock retirement this week, before Cam Jurgens was surprisingly traded to the Ravens. At 2-2, their season is hanging in the balance.

On defense, star cornerback Quinyon Mitchell is also an injury doubt, so when it rains, it pours for Philly. Jalen Carter will have a big role to play in stopping the Jags run game. The Eagles' only previous international game was against Jacksonville at Wembley in 2018, and they won 24-18.

The Jaguars are riding high and have a clear established identity, while the opposite is true for the Eagles. Philadelphia's long list of injuries, as well as the loss of two pillars of the offensive line in a week, should be too much to overcome. Jacksonville are very used to the routine of international games by now, and their opportunistic defense should be able to capitalise on Philly's dysfunctional offense.

Prediction: Jaguars 28-16 Eagles

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All odds and markets are correct as of the date of publication.