2025/26 Premier League GW2 odds & picks: Bets we'd make now

After an eye-catching opening weekend of top-flight football, Ladbrokes runs through its Premier League GW2 odds and picks, highlighting bets we'd make now.

Last weekend saw a few surprises, some eye-catching performances, and plenty of goals - and we're choosing five standout bets to place right now as a result, including a tip for plenty of goals at St. James' Park when Newcastle host Liverpool.

From clear relegation favourites to the Golden Boot race, we've covered all angles here - so let's dive in!

Premier League champions Liverpool - who are also favourites to retain their crown this season - kicked off the season with a high-scoring win under the lights at home to Bournemouth, and we're expecting another goal-fest when they travel to Newcastle on Monday night.

Of the six goals in that 4-2 win, five of them came in the second half, highlighting just how much the game stretched after the break. We'd expect Newcastle to exploit any space Liverpool allow them, just as Bournemouth did, with sheer pace up top and a hunger to pick up their first win of the season.

At the other end, Liverpool boast a handful of the best players in the league - including recently crowned PFA Player of the Year Mohamed Salah - so they will always threaten. As the game opens up in the second half and the teams start to find a bit more space in the final third, the goals could certainly start to flow.

One of the biggest stories of the opening weekend was Sunderland's thumping win at home to West Ham, so we couldn't ignore the Black Cats in this selection of Premier League GW2 odds & picks.

Despite Burnley's outrageous defensive record in the Championship last season, conceding just 16 goals across 46 matches, we're tipping Sunderland to use the momentum of last weekend's result and breach the Clarets' defence more than once - just as Spurs managed to do on Saturday afternoon.

Being at home, Burnley are likely to try and be a bit more expansive with their football, particularly against a fellow newly-promoted team, which will leave space for the likes of Eliezer Mayenda and Chemsdine Talbi to exploit. In what could easily prove to be a relegation six-pointer, we think their respective moods following gameweek 1 could play a huge part when Burnley host Sunderland.

The Golden Boot race is always one that Man City's Erling Haaland will have his eyes on before a ball is even kicked - and after scoring twice against Wolves on the opening day, the big striker has hit the ground running in the 2025/26 campaign.

His record against Spurs is pretty strong, scoring four times in six Premier League meetings, so we're backing him to find the back of the net again when City host Tottenham on Saturday lunchtime. He already tops the scoring charts after his brace last week, and will be eager to catch up on lost time after missing a chunk of last season through injury.

Haaland has won the Golden Boot in two of his three PL campaigns, and if his performance last week is anything to go by, it will be difficult for anyone to stop him reclaiming the award this time around - and we think Spurs could learn that the hard way this weekend.

Looking slightly longer term, we're tipping Scott Parker's Burnley to be relegated at the end of the season, with that opening-day defeat to Spurs coming as no surprise to a lot of people.

There's no shame in losing to Spurs, but the way their fellow relegation favourites performed across the weekend does hint at Burnley being in severe trouble. Both Sunderland and Leeds picked up valuable home wins against established Premier League teams, and both teams' deafening crowds helped drag them over the line - something not necessarily associated with Burnley and Turf Moor.

It would be a huge shock to see all three promoted sides survive this season, and the way they performed on gameweek 1, we think Burnley could face an immediate relegation in May.

We've already spoken about Sunderland's opening-day drubbing of West Ham from the home side's perspective, but from the West Ham POV, that was a disastrous result to kick-off the new season.

A decent pre-season had Hammers fans full of optimism ahead of the first match, with hope that they could show their Premier League class. But they were ultimately humbled by a relentless Sunderland side, and the pressure has really piled up on Graham Potter as a result.

At the time of writing, the Englishman is priced at just 3/1 to be the next Premier League manager to leave, and having won just three of his last 12 games in charge, it wouldn't be a surprise to see him relieved of his duties in the coming weeks. West Ham have a difficult run of fixtures, playing Chelsea this weekend before Forest, Spurs and Palace await - so we think Potter's reign as Hammers boss could be over very soon.

So that concludes our look at the 2025/26 Premier League GW2 odds & picks, with some select bets that we would make ahead of the latest round of matches. For more Premier League betting tips, check out our weekly Premier League acca, and get insight into every match with our detailed match previews.

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All odds and markets are correct as of the date of publication.