2025/26 FA Cup fixtures & predictions: The quarter-finals

Chelsea vs Port Vale

• Our prediction: Chelsea 4-1 Port Vale

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Port Vale have been the story of the FA Cup so far, but we're tipping their fairytale to end this weekend at the hands of Chelsea. The Blues have beaten lower-league opposition to get to this stage, and we're tipping them to do it once again against the League One side on Saturday.

Southampton vs Arsenal

• Our prediction: Southampton 0-2 Arsenal

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Southampton haven't lost a game since mid-January, but we're expecting that run to end at the hands of Arsenal on Saturday evening. Whether Mikel Arteta is without several of his key players, or if that was nothing more than some international break trickery, remains to be seen, but we still think the Gunners have enough to beat the Championship outfit this weekend.

West Ham vs Leeds

• Our prediction: West Ham 2-1 Leeds

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The second of the all-Premier League ties in the quarter-finals of the FA Cup sees Leeds travel down south to face West Ham. The Hammers did well to beat Brentford on penalties in the last round, and we're tipping them to progress once again this weekend, beating Daniel Farke's Leeds in a tightly-fought encounter.

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All odds and markets are correct as of the date of publication.