Liverpool vs Atletico Madrid: Champions League betting tips, odds and predictions

• Liverpool are expected to beat Atletico Madrid on Wednesday night

• An end-to-end game could be on the cards with both teams scoring

• Mohamed Salah is tipped to have a shot on target, with Atleti midfielder Johnny Cardoso picking up a yellow card

The 2025/26 Champions League gets underway this week with Liverpool, one of the outright favourites, starting with a difficult game against Atletico Madrid in the league phase.

Premier League champions Liverpool have kicked off their league campaign with four victories from four and they will hope for more success when Diego Simeone's side come to Anfield on Wednesday evening.

The LaLiga outfit knocked Liverpool out in the last 16 when they were defending European champions in 2019-20, but the Reds won both group games in their last meetings in the competition in 2021-22.

Ahead of what should be an action-packed evening, check out the latest odds, tips and predictions for your Bet Builder.

While Liverpool have won all their games so far this season, Atleti have made a slow start in LaLiga, winning just one out of five so far.

The Reds have home advantage and momentum and with stars like Julian Alvarez an injury doubt for the visitors, we're backing a Liverpool win.

Simeone is infamous for his pragmatic approach in the latter stages of the Champions League but with much less riding on this league phase match, we expect them to take the game to the hosts a little more.

Arne Slot's new-look attacking side have shown some defensive vulnerabilities and, with Atleti still possessing plenty of quality going forward, we could have another end-to-end game at Anfield.

It is not known whether £125million man Alexander Isak will be involved after missing Sunday's win at Burnley so it makes sense to bank on Mohamed Salah for this game.

The Egyptian has 47 goals in 88 Champions League appearances and, though he has arguably underperformed so far this season, he has still proved he knows where the goal is with two goals so far, including the winner from the spot at Turf Moor.

Atletico have picked up an eye-catching seven yellow cards already this season and will be looking to disrupt Slot's men from dominating on the ball with a physical approach.

Midfielder Johnny Cardoso leads the way with two yellow cards and looks like the man to target in the bookings market.

You can bet on all these outcomes individually or lump them together into a four-fold accumulator, which combines for a 13/2 bet at the time of writing.

Check out our Champions League accumulator tips, which backs wins for Liverpool and Manchester City but defeats for Chelsea and Newcastle.

With Bet Builder+, you can combine your football bets with a host of other sports bets.

Check out our Champions League draw article for Liverpool and the other favourites' fixtures in the league phase, as well as the games to watch out for.

View the latest football odds.

All odds and markets are correct as of the date of publication.