Arsenal vs Manchester City: Predictions, Odds, Lineups, Preview

• Arsenal to keep the pressure on league leaders Liverpool with the prediction of a 2-1 win at home to Manchester City.

• Mikel Arteta's side have only conceded in one game this season, but Ladbrokes is tipping Man City to find the back of the net.

• Gabriel will be key to Arsenal's efforts of keeping Erling Haaland quiet, with the pair establishing somewhat of a rivalry over the last few years.

Explore Ladbrokes’ detailed preview for Arsenal vs Manchester City in the Premier League. Stats, odds, predictions, and lineups for the 16:30 BST match.

• Fixture: Arsenal vs Manchester City

• Date: Sunday, 21 September 2025

• Kick-off: 16:30 BST

• Venue: Emirates Stadium

Match Prediction: Arsenal 2-1 Manchester City

Arsenal's recent form has been solid, with three wins in their last four league games, including a convincing 3-0 victory over Nottingham Forest at home. Arsenal has displayed solid form recently, securing three victories in their last four league matches, notably a decisive 3-0 home win against Nottingham Forest. They'll be looking to exploit their home advantage again, using their attacking flair to break down City's defence.

Manchester City, on the other hand, have had a mixed bag, with two losses in their last four league outings, but they showed their class with a 3-0 win against arch-rivals Manchester United in the derby. Expect City to come out strong, but Arsenal's momentum and home support might just tip the scales.

The game could be a tactical battle, with Arsenal likely to press high and try to force errors from City's backline. The City will look to control possession and hit Arsenal on the counter, utilising the pace of their forwards. It's set to be a close contest, but Arsenal's recent form and home advantage could make the difference.

Arsenal are in excellent form, having won three of their last four league matches, including a commanding 5-0 victory at home against Leeds United. Their only loss of the Premier League campaign so far came away to Liverpool, but they bounced back with a 3-0 home win over Nottingham Forest. 

This run of form suggests they're hitting their stride at the right time, and they'll be confident heading into this match. Their attacking prowess and ability to grind out results could be key against a strong Manchester City side.

Recent Premier League Results:

• Win: 3-0 vs Nottingham Forest (H)

• Loss: 0-1 vs Liverpool (A)

• Win: 5-0 vs Leeds United (H)

• Win: 1-0 vs Manchester United (A)

Manchester City’s start to the season has been highly inconsistent, with two losses in their last four league games, including a surprising 0-2 defeat at home to Tottenham Hotspur. However, they showed their quality with a 3-0 win over Manchester United at home and a 4-0 thrashing of Wolves away.

Their quality, however, was evident in a 3-0 home victory against Manchester United and a dominant 4-0 away win over Wolves. This inconsistency might be a concern, but City have the talent to turn it around. They'll need to be at their best to overcome Arsenal's current form and home advantage.

Recent Premier League Results:

• Win: 3-0 vs Manchester United (H)

• Loss: 1-2 vs Brighton & Hove Albion (A)

• Loss: 0-2 vs Tottenham Hotspur (H)

• Win: 4-0 vs Wolverhampton Wanderers (A)

Arsenal have had the upper hand in recent meetings, winning two of the last five encounters, with the other three games in the run ending in draws. Their most recent victory was a convincing 5-1 win over Manchester City, showing they can dominate when at their best.

Recent Results (All competitions)

• Arsenal 5-1 Manchester City (02 Feb 2025)

• Manchester City 2-2 Arsenal (22 Sep 2024)

• Manchester City 0-0 Arsenal (31 Mar 2024)

• Arsenal 1-0 Manchester City (08 Oct 2023)

• Arsenal 1-1 Manchester City (06 Aug 2023)

• Gabriel Jesus (Knee) - Out

• Kai Havertz (Knee) - Out

• Bukayo Saka (Hamstring) - Out

• Martin Odegaard (Ankle) - Doubt

• Rayan Cherki  (Thigh) - Out

• Omar Marmoush (Knee) - Out

• Rayan Aït-Nouri (Ankle) - Doubt

• Raya, Timber, Saliba, Magalhães, Calafiori, Zubimendi, Rice, Nwaneri, Madueke, Gyökeres, Eze

Arsenal's predicted lineup suggests they'll continue to rely on their attacking trio of Gyökeres, Madueke, and Eze to create and score goals. The midfield trio of Rice, Zubimendi, and Nwaneri will be crucial in controlling the game and breaking down City's midfield.

• Donnarumma, Khusanov, Dias, Gvardiol, O’Reilly, Rodri, Silva, Reijnders, Foden, Doku, Haaland

Manchester City's predicted lineup indicates they'll look to Haaland and Doku to lead their attack, with Rodri and Silva providing the creativity and control in midfield. The defence, led by Dias and Gvardiol, will need to be solid to handle Arsenal's attacking threat.

• Gyökeres vs Dias: Gyökeres' pace and finishing will be tested against Dias' defensive solidity.

• Ødegaard vs Rodri: Ødegaard's creativity will be crucial in breaking down Rodri's midfield control.

• Eze (Arsenal): Eze's flair and ability to unlock defences could be key for Arsenal.

• Haaland (Manchester City): Haaland's goal-scoring prowess will be vital for City to get a result.

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Odds and market details are accurate as of the time of publication.