Benfica vs Bayer Leverkusen: Predictions, Betting odds, Lineups, Preview

Explore Ladbrokes' detailed preview for Benfica vs Bayer Leverkusen in the UEFA Champions League. Stats, odds, predictions, and lineups for the 20:00 GMT match.

• Fixture: Benfica vs Bayer Leverkusen

• Date: Wednesday, 05 November 2025

• Kick-off: 20:00 GMT

• Venue: Estádio do Sport Lisboa e Benfica

Benfica's recent form has been a bit of a rollercoaster, but they've shown they can dig in and get results at home. They'll need to be sharp against a Bayer Leverkusen side that's been leaky at the back but dangerous going forward. Expect Benfica to press high and try to exploit Leverkusen's defensive frailties, while Leverkusen will look to hit them on the break.

Leverkusen, despite their heavy loss to PSG, have shown they can score goals against tough opposition. They'll need to be more solid at the back if they want to get anything from this game. It could be an open, end-to-end affair with both teams looking to attack.

Benfica's recent form has been patchy, with three losses in their last five games. However, their home win against Fenerbahce shows they can still grind out results when needed. They'll need to be more clinical in front of goal if they want to beat Leverkusen, but their home form could be the key to getting a positive result.

• Loss: 0-3 vs Newcastle (A)

• Loss: 0-1 vs Chelsea (A)

• Loss: 2-3 vs Qarabag (H)

• Win: 1-0 vs Fenerbahce (H)

• Draw: 0-0 vs Fenerbahce (A)

Leverkusen have had a tough time recently, with a heavy defeat to PSG and two draws against PSV and Copenhagen. They've shown they can score goals, but their defense has been a real concern. If they can shore up at the back, they could cause Benfica problems, but it won't be easy on the road.

• Loss: 2-7 vs Paris Saint Germain (H)

• Draw: 1-1 vs PSV Eindhoven (H)

• Draw: 2-2 vs FC Copenhagen (A)

The last time these two teams met, they played out a goalless draw in 2014. Before that, Leverkusen beat Benfica 3-1 at home. It's been a while since they last faced each other, but Leverkusen have the edge in their recent head-to-head record.

• Benfica 0-0 Bayer Leverkusen (09 Dec 2014)
• Bayer Leverkusen 3-1 Benfica (01 Oct 2014)

• A. Bah (Knee Injury) - Out

• Bruma (Achilles Tendon Injury) - Out

• G. Prestianni (Inactive) - Out

• Manu (Knee Injury) - Out

• E. Palacios (Groin Injury) - Out

• M. Tillman (Muscle Injury) - Out

• N. Tella (Knee Injury) - Out

• A. Tape (Hamstring Injury) - Doubt

• Lucas (Muscle Injury) - Doubt

• Predicted lineup: Trubin (GK), Dedic (DF), Silva (DF), Otamendi (DF), Araujo (DF), Aursnes (DF), Lukebakio (MF), Rios (MF), Barrenechea (MF), Sudakov (MF), Pavlidis (AT)

With key players like Rios and Sudakov in midfield, Benfica will look to control the game and create chances for Pavlidis up front. Their defense, led by Otamendi, will need to be solid to keep Leverkusen's attackers at bay.

• Predicted lineup: Flekken (GK), Bade (DF), Tapsoba (DF), Andrich (MF), Arthur (MF), Fernandez (MF), Garcia (MF), Grimaldo (MF), Echeverri (MF), Poku (AT), Kofane (AT)

Leverkusen's attacking trio of Echeverri, Poku, and Kofane will be crucial in breaking down Benfica's defense. With Fernandez and Garcia in midfield, they'll look to control the tempo and hit Benfica on the counter.

• Pavlidis vs Tapsoba: This will be a key battle between Benfica's striker and Leverkusen's central defender.
• Rios vs Fernandez: The midfield duel between Benfica's Rios and Leverkusen's Fernandez could dictate the flow of the game.
• Sudakov (Benfica): Sudakov's creativity in midfield will be vital for Benfica's attacking play.
• Poku (Bayer Leverkusen): Poku's pace and finishing ability make him a constant threat for Leverkusen up front.

Fans in the UK are able to watch Benfica vs Bayer Leverkusen on TNT Sports 6 at 20:00 GMT on Wednesday, 05 November 2025

Ladbrokes is predicting that the score will be 2-1 in the match between Benfica and Bayer Leverkusen

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