Chelsea vs Ajax: Predictions, Betting odds, Lineups, Preview

Explore Ladbrokes' detailed preview for Chelsea vs Ajax in the Champions League. Stats, odds, predictions, and lineups for the 20:00 BST match.

• Fixture: Chelsea vs Ajax
• Date: Wednesday, 22 October 2025
• Kick-off: 20:00 BST
• Venue: Stamford Bridge

Chelsea's recent form shows they can be solid at home, as seen in their 1-0 win against Benfica. They'll look to control the game with their midfield trio of Neto, Fernández, and Caicedo, aiming to exploit Ajax's shaky defence. However, their loss to Bayern Munich away suggests they need to be more clinical in front of goal. Expect Chelsea to dominate possession and create chances, but they must convert them to secure the win.

Ajax, on the other hand, have struggled lately, losing 0-4 to Marseille and 0-2 to Inter. Their attack, led by Weghorst, Gloukh, and Godts, needs to step up if they're to challenge Chelsea. Defensively, they'll have their work cut out against Chelsea's attacking threats. Ajax might try to hit Chelsea on the break, but it'll be tough for them to get a result away from home.

Chelsea's recent results show a mixed bag. They managed a solid 1-0 win at home against Benfica, which suggests they can be tough to beat on their own turf. However, their 1-3 loss to Bayern Munich away indicates they need to improve their away form. At home against Ajax, they'll be looking to build on their defensive solidity and make the most of their attacking options.

Recent Champions League results:

• Win: 1-0 vs Benfica (H)
• Loss: 1-3 vs FC Bayern München (A)

Ajax have been struggling lately, with heavy defeats to Marseille and Inter. Their defence has been particularly leaky, conceding six goals in those two games. On the attack, they've been unable to find the net, which is a concern. Facing Chelsea away, Ajax will need to tighten up at the back and be more clinical in front of goal if they're to have any chance of getting a result.

Recent Champions League results:

• Loss: 0-4 vs Olympique Marseille (A)
• Loss: 0-2 vs Inter (H)

Chelsea and Ajax have met twice recently, and both games were close. Chelsea won 1-0 away in a previous encounter, while Ajax secured a 4-4 draw in London. These results suggest that both teams can be competitive against each other, but Chelsea have the edge in recent meetings.

Recent Champions League results:

• Chelsea 4-4 Ajax (05 Nov 2019)

• Ajax 0-1 Chelsea (23 Oct 2019)

• Dario Essugo (Thigh) - Out

• Liam Delap (Hamstring) - Out

• Levi Colwill (Knee) - Out

• Mykhailo Mudryk (Suspended) - Out

• Cole Palmer (Groin) - Doubt

• João Pedro (Suspended) - Out

• Enzo Fernandez (Knee) - Doubt

• Reece James (Leg) - Doubt

• Tosin Adarabioyo (Calf) - Doubt

• Wesley Fofana (Head) - Doubt

• Kasper Dolberg (Stomach) - Doubt

• Branco van den Boomen (Back) - Doubt

• Owen Wijndal (Unknown) - Doubt

• Youro Reeger (Unknown) - Doubt

Predicted lineup: Sánchez (GK), James (DF), Acheampong (DF), Chalobah (DF), Cucurella (DF), Caicedo (MF), Fernández (if fit) (MF), Neto (MF), Santos (MF), Garnacho (MF), Guiu (AT)

Chelsea's predicted lineup suggests a strong midfield presence with Neto, Fernández, and Caicedo, which should help them control the game. Up front, Guiu will be looking to make an impact and provide the cutting edge they lacked against Bayern.

Predicted lineup: Jaros (GK), Gaaei (DF), Sutalo (DF), Baas (DF), Rosa (DF), Mokio (MF), Taylor (MF), Edvardsen (MF), Gloukh (AT), Godts (AT), Weghorst (AT)

Ajax's predicted lineup indicates they'll rely on their attacking trio of Gloukh, Godts, and Weghorst to cause problems for Chelsea's defence. Defensively, Baas and Rosa will need to be at their best to contain Chelsea's attacking threats.

• Alejandro Garnacho vs Lucas Rosa: This will be a key battle between Chelsea's attacker and Ajax's experienced defender.

• Moises Caicedo vs Oliver Edvardsen: Chelsea's dynamic midfielder will look to dominate the midfield against Ajax's talented creator.

• Pedro Neto (Chelsea): Neto's creativity and vision in midfield will be crucial for Chelsea's attacking play.

• Wout Weghorst (Ajax): His experience and goal-scoring threat make him a key player for Ajax's attack.

Fans in the UK are able to watch Chelsea vs Ajax on TNT Sports 2 and TNT Sports Ultimate at 20:00 BST on Wednesday, 22 October 2025

Ladbrokes is predicting that the score will be Chelsea 2-0 Ajax. in this match

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Odds and market details are accurate as of the time of publication.