Derby County vs Southampton: Predictions, Betting odds, Lineups, Preview

Explore Ladbrokes' detailed preview for Derby County vs Southampton in the Championship. Stats, odds, predictions, and lineups for the 15:00 BST match.

• Fixture: Derby County vs Southampton

• Date: Saturday, 04 October 2025

• Kick-off: 15:00 BST

• Venue: Pride Park Stadium

Match Prediction: Derby County 2-1 Southampton

Derby County's recent form has been a rollercoaster, with draws and a loss mixed in with a solid win. They'll need to be sharp against Southampton, who've shown they can nick points on the road.

Derby's attack might find some joy against Southampton's defence, which has been leaky at times. Expect a tight game where Derby's home advantage could play a significant role.

Southampton have been inconsistent but capable of pulling off wins away from home. Their draw-heavy run suggests they can hold their own but struggle to secure wins. 

They'll need to be more clinical if they want to take all three points from Derby. This match could go either way, but Southampton's recent results suggest they should not be underestimated.

Derby's recent league form has been inconsistent, with three draws, a loss, and a win in their last five games. The win against West Brom shows they can grind out results when needed. However, the draws and losses indicate they need to be more decisive in front of goal. 

If they can carry the momentum from their win and tighten up at the back, they could pose a real threat to Southampton.

• Draw: 1-1 vs Charlton Athletic (H)

• Draw: 1-1 vs Wrexham (A)

• Loss: 0-1 vs Preston North End (H)

• Win: 1-0 vs West Bromwich Albion (A)

• Draw: 2-2 vs Ipswich Town (A)

Southampton have had a mixed bag of results lately, with a win, three draws, and a loss. Their ability to draw games shows they can compete, but the loss to Hull City highlights their vulnerability. 

The win against Sheffield United proves they can perform on the road, which will be crucial against Derby. If they can shore up their defence and be more ruthless in attack, they stand a good chance of getting a result.

• Win: 2-1 vs Sheffield United (A)

• Draw: 1-1 vs Middlesbrough (H)

• Loss: 1-3 vs Hull City (A)

• Draw: 0-0 vs Portsmouth (H)

• Draw: 2-2 vs Watford (A)

Southampton have had the upper hand in recent meetings, winning three out of the last five encounters. Derby managed a draw in two of those games, but hasn't beaten Southampton since 2007. This history suggests Southampton might have a psychological edge, but Derby will be eager to change that narrative at home.

• Southampton 4-0 Derby County (18 Feb 2012)

• Derby County 1-1 Southampton (15 Oct 2011)

• Southampton 1-1 Derby County (10 Mar 2009)

• Derby County 0-1 Southampton (23 Aug 2008)

• Derby County 2-3 Southampton (15 May 2007)

• Rhian Brewster (Groin) - Out

• Liam Thompson (Hip) - Out

• Corey Blackett-Taylor (Hamstring) - Out

• Curtis Nelson (Knee) - Out

• Owen Beck (Hamstring) - Doubt

• Welington (Ankle) - Out

• Cameron Archer (Hamstring) - Out

• Samuel Udozie (Knock) - Doubt

• Flynn Downes (Illness) - Doubt

• Predicted lineup: Zetterström, Johnston, Sanderson, Elder, Clarke, Travis, Adams, Clark, Morris, Brereton, Agyemang

With Johnston and Clark in the lineup, Derby will look to exploit Southampton's defence with quick counter-attacks. The midfield duo of Travis and Adams will need to control the game's tempo and provide solid support to the backline.

• Predicted lineup: McCarthy, Edwards, Wood, Quarshie, Manning, Jander, Charles, Fellows, Azaz, Armstrong, Stewart

Southampton's predicted lineup suggests they'll rely on Azaz and Stewart for attacking inspiration. The midfield pairing of Charles and Jander will be key in breaking down Derby's midfield and maintaining possession.

• Agyemang vs Quarshie: This will be a crucial battle between Derby's forward Agyemang and Southampton's defender Quarshie.

• Travis vs Jander: The midfield duel between Derby's Travis and Southampton's Jander could dictate the flow of the game.

• Johnston (Derby County): Max Johnston's pace and directness from full-back could be a game-changer for Derby.

• Charles (Southampton): Charles's ability to control the midfield and distribute the ball effectively will be vital for Southampton.

Ladbrokes brings you the most exciting odds to enhance your experience.

For the best Championship outright predictions, explore our guide.

Odds and market details are accurate as of the time of publication.