Manchester City vs Bayer Leverkusen: Predictions, Betting odds, Lineups, Preview

Explore Ladbrokes' detailed preview for Manchester City vs Bayer Leverkusen in the UEFA Champions League. Stats, odds, predictions, and lineups for the 20:00 GMT match.

• Fixture: Manchester City vs Bayer Leverkusen
• Date: Tuesday, 25 November 2025
• Kick-off: 20:00 GMT
• Venue: Etihad Stadium

Manchester City are coming into this match on a strong run of form, having won three of their last four games, including a convincing 4-1 home victory over Borussia Dortmund. Their ability to score goals consistently, as seen in their recent results, suggests they'll look to dominate possession and press high up the pitch against Bayer Leverkusen. The Citizens' attacking flair, led by the likes of Haaland and Doku, could pose significant problems for Leverkusen's defence, which has shown vulnerability, especially in their heavy loss to Paris Saint-Germain.

On the other hand, Bayer Leverkusen have had a mixed bag of results, with a notable win against Benfica but also a crushing defeat to PSG. Their resilience was evident in their draws against PSV Eindhoven and FC Copenhagen, indicating they might set up to counter-attack and exploit any gaps left by Manchester City's aggressive play. However, their injury list is a concern, and it might affect their ability to match City's intensity and tactical flexibility.

Manchester City's recent form has been nothing short of impressive, with three wins and a draw in their last four matches. Their latest victory, a 4-1 thrashing of Borussia Dortmund, showcased their attacking prowess and ability to control games from start to finish.

This strong run of form, coupled with their high-scoring nature, suggests they'll enter the match against Bayer Leverkusen with confidence and a clear game plan to dominate possession and create numerous scoring opportunities.

Recent UEFA Champions League Results:

• Win: 4-1 vs Borussia Dortmund (H)

• Win: 2-0 vs Villarreal (A)

• Draw: 2-2 vs Monaco (A)

• Win: 2-0 vs Napoli (H)

Bayer Leverkusen's recent performances have been a rollercoaster, with a standout win against Benfica but also a demoralising 2-7 loss to Paris Saint-Germain at home. Their ability to grind out results, as seen in their draws against PSV Eindhoven and FC Copenhagen, shows they can be resilient, but their heavy defeat to PSG raises questions about their defensive stability. With several key players out due to injuries and suspensions, Leverkusen will need to dig deep to compete against a formidable Manchester City side.

Recent UEFA Champions League Results:

• Win: 1-0 vs Benfica (A)

• Loss: 2-7 vs Paris Saint-Germain (H)

• Draw: 1-1 vs PSV Eindhoven (H)

• Draw: 2-2 vs FC Copenhagen (A)

Unfortunately, there is no head-to-head data available for Manchester City vs Bayer Leverkusen, so we can't draw on past encounters to predict how this match might unfold. However, given the current form and playing styles of both teams, it's clear that Manchester City's attacking strength will be tested by Leverkusen's resilience and counter-attacking threat.

• Mateo Kovacic (Ankle) - Out

• Axel Tape (Hamstring) - Out

• Exequiel Palacios (Adductor) - Out

• Lucas Vázquez (Muscle) - Out

• Equi Fernandez (Ligament) - Out

• Arthur Augusto (Back) - Out

• Alejandro Grimaldo (Muscle) - Out

• Robert Andrich (Suspended) - Out

• Edmond Tapsoba (Suspended) - Out

• Ernest Poku (Knock) - Doubt

• Nathan Tella (Knee) - Doubt

• Predicted lineup: Donnarumma (GK), Nunes (DF), Dias (DF), Gvardiol (DF), O'Reilly (DF), Nico (MF), Cherki (MF), Silva (MF), Foden (MF), Doku (MF), Haaland (AT)

Manchester City's predicted lineup suggests a focus on maintaining possession and exploiting their attacking midfielders, such as Doku and Cherki. Meanwhile, Haaland's presence up top will be crucial for converting chances into goals.

• Predicted lineup: Flekken (GK), Belocian (DF), Bade (DF), Quansah (DF), Tella (MF)(If fit), Maza (MF), Garcia (MF), Hofmann (MF), Kofane (MF), Poku (MF)(If fit), Schick (AT)

• Bayer Leverkusen's predicted lineup suggests a reliance on counter-attacks, with Kofane, Schick, and Poku leading the charge, while Garcia's defensive and offensive contributions will be vital on the left flank.

• Haaland vs Bade: This matchup will see Manchester City's prolific striker go head-to-head with Leverkusen's versatile defender, who will need to be at his best to contain Haaland's goal-scoring threat.

• Foden vs Garcia: A battle in the midfield where Manchester City's creative force, Foden, will look to outmanoeuvre Leverkusen's experienced star Garcia, who will aim to disrupt City's rhythm.

• Nico (Manchester City): Nico's role will be crucial for Manchester City, as his ability to break up play and distribute the ball effectively could dictate the tempo of the game.

• Kofane (Bayer Leverkusen): Kofane's pace and finishing ability make him a key player for Leverkusen, as he could be the difference in their counter-attacking strategy against Manchester City.

Manchester City vs Bayer Leverkusen at 20:00 GMT on Tuesday, 25 November 2025, will be broadcast live for viewers in the UK on TNT Sports 1 and TNT Sports Ultimate.

Ladbrokes is predicting that the score will be Manchester City 3-1 Bayer Leverkusen.

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