Manchester United vs Chelsea: Predictions, Odds, Lineups, Preview

• Ladbrokes is predicting a 2-1 home win for Manchester United against Chelsea on September 20.

• A win for Man United would only be their second of the season so far, with recent losses to Arsenal and Manchester City.

• Casemiro will be key to controlling the midfield battle against Chelsea, with Moises Caicedo posing a real threat in both boxes.

Explore Ladbrokes’ detailed preview for Manchester United vs Chelsea in the Premier League. Stats, odds, predictions, and lineups for the 17:30 BST match.

• Fixture: Manchester United vs Chelsea

• Date: Saturday, 20 September 2025

• Kick-off: 17:30 BST

• Venue: Old Trafford

Match Prediction: Manchester United 2-1 Chelsea

Manchester United's recent form has been a bit of a rollercoaster, with a heavy loss to Manchester City but a spirited win against Burnley. 

They'll need to be sharp and focused against Chelsea, who've shown they can score goals in bunches, like their 5-1 thrashing of West Ham. United's attack could exploit Chelsea's occasional defensive lapses, but they'll have to be wary of Chelsea's potent counter-attacks.

Chelsea, on the other hand, has been more consistent lately, with two wins and two draws in their last four league outings. Their ability to score against strong teams like West Ham suggests they could trouble United's backline.

However, their draws show they can sometimes struggle to close out games, which might give United a chance to nick a late goal. It should be a tight, tactical battle.

Manchester United's recent form has been up and down, with a crushing defeat to Manchester City but a hard-fought win against Burnley. Their loss to Arsenal at home shows they can be vulnerable, especially against top teams.

This inconsistency might make them unpredictable, but if they can harness the energy from their win against Burnley, they could pose a real threat to Chelsea.

The absence of Lisandro Martínez due to a cruciate ligament injury is a blow, but their lineup still boasts quality players like Bruno Fernandes and Luke Shaw. If they can keep their heads and play to their strengths, they have a good chance of getting a result against Chelsea.

Recent Premier League Results:

• Loss: 0-3 vs Manchester City (A)

• Win: 3-2 vs Burnley (H)

• Draw: 1-1 vs Fulham (A)

• Loss: 0-1 vs Arsenal (H)

Chelsea have been in decent form, with two wins and two draws in their last four league games. Their ability to score five against West Ham shows they can be ruthless in attack, but their draws against Brentford and Crystal Palace indicate they sometimes struggle to kill off games. This could be crucial against a Manchester United side that can be dangerous on the break.

The injury to Dário Essugo is a setback, but their predicted lineup still looks strong, with players like Enzo Fernández and João Pedro capable of making a difference. If they can maintain their attacking momentum and tighten up at the back, they should be confident of getting a positive result at Old Trafford.

Recent Premier League Results:

• Draw: 2-2 vs Brentford (A)

• Win: 2-0 vs Fulham (H)

• Win: 5-1 vs West Ham United (A)

• Draw: 0-0 vs Crystal Palace (H)

Historically, the head-to-head record between Manchester United and Chelsea has been closely contested, with both teams having recent wins and draws. Chelsea have won two of the last five encounters, while Manchester United have won two, with one draw, suggesting neither team has a clear upper hand.

Recent Premier League Results

• Chelsea 1-0 Manchester United (16 May 2025)

• Manchester United 1-1 Chelsea (03 Nov 2024)

• Chelsea 4-3 Manchester United (04 Apr 2024)

• Manchester United 2-1 Chelsea (06 Dec 2023)

• Manchester United 4-1 Chelsea (25 May 2023)

• LLisandro Martínez (Knee) - Out

• Mason Mount (Knock) - Out

• Matheus Cunha (Hamstring) - Out

• Diego Dalot (Muscle) - Out

• Dário Essugo (Thigh) - Out

• Liam Delap (Hamstring) - Out

• Levi Colwill (Knee) - Out

• Benoît Badiashile (Fitness) - Doubt

• Bayındır, Yoro, De Ligt, Shaw, Mazraoui, Fernandes, Ugarte, Dorgu, Mbeumo, Diallo, Sesko

With Bruno Fernandes and Noussair Mazraoui in the lineup, Manchester United will look to control the midfield and exploit the flanks. Their recent form suggests they need to be more solid defensively to counter Chelsea's attacking threat.

• Sánchez, James, Adarabioyo, Chalobah, Cucarella, Fernández, Caicedo, Neto, Palmer, Gittens, Pedro

Chelsea's predicted lineup, featuring Enzo Fernández and João Pedro, indicates they'll aim to dominate possession and create chances through the middle. Their recent results show they need to be more clinical in front of goal to secure a win against Manchester United.

• Bruno Fernandes vs. Enzo Fernández: A midfield battle that could dictate the game's tempo.

• Luke Shaw vs. Pedro Neto: A crucial duel on the left flank that could influence the outcome.

• Amad Diallo (Manchester United): His pace and creativity could be key to unlocking Chelsea's defence.

• João Pedro (Chelsea): His goal-scoring form makes him a constant threat to Manchester United's backline.

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Odds and market details are accurate as of the time of publication.