Real Madrid vs Juventus: Predictions, Betting odds, Lineups, Preview

• Fixture: Real Madrid vs Juventus
• Date: Wednesday, 22 October 2025
• Kick-off: 20:00 BST
• Venue: Estadio Santiago Bernabéu

Real Madrid are coming into this match with a bang, smashing Kairat 5-0 away and edging Olympique Marseille 2-1 at home. They're in top form, and their attacking flair could be too much for Juventus to handle. Expect Real Madrid to dominate possession and create plenty of chances, especially with Mbappé leading the line.

Juventus, on the other hand, have been drawing left, right, and centre, with 2-2 against Villarreal and a wild 4-4 against Borussia Dortmund. They'll need to tighten up at the back if they want to stand a chance against Real Madrid's firepower. It might be a tough night for them, but they could nick a goal on the break.

Real Madrid are on fire right now, with two convincing wins under their belt. They've been scoring for fun and look solid at the back, which bodes well for this match. With Mbappé in top form, they'll be confident of getting the job done against Juventus.

Their recent results show they can handle pressure and keep their cool in front of goal. This should give them the edge they need to come out on top in what promises to be an exciting clash.

Recent Champions League results:

• Win: 5-0 vs Kairat (A)

• Win: 2-1 vs Olympique Marseille (H)

Juventus have been struggling to find consistency, drawing their last two games and conceding plenty of goals. They'll need to be more disciplined if they want to stop Real Madrid's attacking threat. It won't be easy, but they've got the players to cause problems on the counter.

Their recent form suggests they might be vulnerable at the back, which could be a big problem against a team like Real Madrid. They'll need to be at their best to get anything out of this game.

Recent Champions League results:

• Draw: 2-2 vs Villarreal (A)

• Draw: 4-4 vs Borussia Dortmund (H)

Real Madrid and Juventus have had some epic battles in the past. Juventus got the better of Real Madrid in their last meeting in 2018, winning 3-1. But Real Madrid have had their moments too, with a 3-0 win in Turin and a 4-1 victory in the 2017 Champions League final. It's always a close contest between these two giants.

Recent Champions League results:

• Real Madrid 1-3 Juventus (11 Apr 2018)
• Juventus 0-3 Real Madrid (03 Apr 2018)
• Juventus 1-4 Real Madrid (03 Jun 2017)
• Real Madrid 1-1 Juventus (13 May 2015)
• Juventus 2-1 Real Madrid (05 May 2015)

• Trent Alexander-Arnold (Hamstring) - Out 

• Antonio Rüdiger (Muscle) - Out

• Dani Carvajal (Suspended) - Out

• Dani Ceballos (Muscle) - Out

• Dean Huijsen (Muscle) - Doubt

• Franco Mastantuono (Knock) - Doubt

• Ferland Mendy (Thigh) - Doubt

• Juan Cabal (Hamstring) - Out

• Bremer (Meniscus) - Out

• Carlo Pinsoglio (Leg) - Out

• Fabio Miretti (Hamstring) - Doubt

Predicted lineup: Courtois, Valverde, Militão, Alaba, Carreras, Tchouaméni, Camavinga, Rodrygo, Güler, Vinícius Júnior, Mbappé

With Mbappé up top and a strong midfield trio of Camavinga, Tchouaméni, and Güler, Real Madrid will look to control the game and exploit Juventus' defensive weaknesses. The backline of Valverde, Militão, Alaba and Carreras should provide a solid foundation, allowing the team to push forward with confidence.

Predicted lineup: Di Gregorio, Gatti, Rugani, Kelly, Kalulu, McKennie, Locatelli, Cambiaso, Conceição, Yıldız, David

Juventus will rely on the experience of Locatelli and McKennie in midfield to try and disrupt Real Madrid's rhythm and launch quick counter-attacks. The defensive trio of Gatti, Kelly, and Rugani will need to be at their best to contain Mbappé and Real Madrid's attacking threat.

• Mbappé vs Rugani: This will be a crucial battle, with Mbappé's pace and skill up against Rugani's defensive nous.

• Güler vs McKennie: Güler's creativity will be tested by McKennie's energy and tenacity in the midfield.

• Güler (Real Madrid): Güler's ability to control the tempo and pick out key passes will be vital for Real Madrid's attacking play.

• Locatelli (Juventus): Locatelli's role in midfield will be crucial for Juventus, as he looks to break up play and start counter-attacks.

Fans in the UK are able to watch Real Madrid vs Juventus at 20:00 BST on Wednesday, 22 October 2025, on TNT Sports 5.

Ladbrokes is predicting that the score will be Real Madrid 3-1 Juventus.

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For the best Champions League outright predictions, explore our guide.

Odds and market details are accurate as of the time of publication.