Sheffield United vs Southampton: Predictions, Betting odds, Lineups, Preview

Explore Ladbrokes' detailed preview for Sheffield United vs Southampton in the Championship. Stats, odds, predictions, and lineups for the 19:45 BST match.

• Fixture: Sheffield United vs Southampton

• Date: Tuesday, 30 September 2025

• Kick-off: 19:45 BST

• Venue: Bramall Lane

Match Prediction: Sheffield United 1-1 Southampton

Sheffield United are coming off a mixed bag of results, with a win against Oxford United but four losses in their previous four games. They'll need to tighten up at the back after conceding heavily against Ipswich Town. Southampton, on the other hand, have been drawing a lot lately, showing they can hold their own but struggle to finish games off. This match could be tight, with Sheffield United looking to exploit Southampton's defensive frailties.

Southampton's recent form suggests they're tough to beat but also tough to trust for a win. They've drawn three of their last five, showing resilience but a lack of cutting edge. Sheffield United, despite their recent losses, have shown they can nick a win when it counts, as seen against Oxford. Expect a close game where both teams will be looking to break their respective streaks.

Sheffield United's recent form has been a rollercoaster, with a single win against Oxford United preceded by four losses. Their defence has been particularly leaky, conceding five goals to Ipswich Town. This could be a concern against Southampton, who, despite their struggles, can still pose a threat. If Sheffield United can shore up their defence, they might just turn their fortunes around.

The Blades will need to capitalise on their home advantage and the momentum from their win against Oxford. Their attack showed promise in that game, and if they can replicate that performance they stand a good chance of getting something from this match.

• Win: 1-0 vs Oxford United (A)

• Loss: 0-1 vs Charlton Athletic (H)

• Loss: 0-5 vs Ipswich Town (A)

• Loss: 0-1 vs Middlesbrough (A)

• Loss: 0-1 vs Millwall (H)

Southampton have been drawing a lot recently, with three draws in their last five games. This shows they're hard to beat but also struggle to secure wins. Their defence has been solid enough, but their attack needs to step up if they want to come away with three points from this game.

The Saints will need to be more clinical in front of goal if they're to break their cycle of draws. Their recent performances suggest they can compete, but they'll need to find that extra gear to overcome Sheffield United's home advantage.

• Draw: 1-1 vs Middlesbrough (H)

• Loss: 1-3 vs Hull City (A)

• Draw: 0-0 vs Portsmouth (H)

• Draw: 2-2 vs Watford (A)

• Loss: 1-2 vs Stoke City (H)

The head-to-head record between these two teams shows a competitive history, with Sheffield United winning two, Southampton winning two, and one draw in their last five encounters. The most recent match in 2009 saw Sheffield United come out on top with a 2-1 victory away at Southampton. This suggests that both teams have had their moments of dominance, making for an unpredictable clash.

• Southampton 1-2 Sheffield United (03 Feb 2009)

• Sheffield United 0-0 Southampton (21 Oct 2008)

• Southampton 3-2 Sheffield United (04 May 2008)

• Sheffield United 1-2 Southampton (29 Sep 2007)

• Sheffield United 3-0 Southampton (25 Mar 2006)

• Jamie Shackleton (Foot) - Doubt

• Tom Davies (Muscle) - Doubt

• Ollie Arblaster (Leg) - Doubt

• Welington (Ankle) - Doubt

• Samuel Edozie (Knock) - Doubt

• Predicted lineup: Cooper, Tanganga, McGuinness, Mee, Burrows, Hamer, Peck, Ogbene, O’Hare, Soumaré, Campbell

With Hamer and O'Hare in midfield, Sheffield United will look to control the game and create chances for their forwards. The defence, led by Tanganga, will need to be solid to prevent Southampton from exploiting their recent vulnerabilities.

• Predicted lineup: McCarthy, Edwards, Wood, Quarshie, Manning, Jander, Charles, Fellows, Azaz, Armstrong, Stewart

Southampton's attack, spearheaded by Armstrong and Stewart, will be crucial in breaking down Sheffield United's defence. The midfield, with Azaz and Jander, will need to be disciplined to counter Sheffield United's midfield dominance.

• Gustavo Hamer vs Ryan Manning: This will be a key battle on the flank between Sheffield United's creative midfielder and Southampton's experienced defender.

• Harrison Burrows vs Tom Fellows: Expect an interesting tussle as Sheffield United's left-back Burrows tries to out-think Southampton's tricky winger Fellows.

• Chiedozie Ogbene (Sheffield United): Ogbene's pace and directness could be crucial for Sheffield United's attacking threat.

• Finn Azaz (Southampton): His ability to control the midfield and to find space could be vital for Southampton's chances of securing a result.

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