Sheffield Wednesday vs Middlesbrough: Predictions, Betting odds, Lineups, Preview

Explore Ladbrokes' detailed preview for Sheffield Wednesday vs Middlesbrough in the Championship. Stats, odds, predictions, and lineups for the 20:00 BST match.

• Fixture: Sheffield Wednesday vs Middlesbrough

• Date: Wednesday, 22 October 2025

• Kick-off: 20:00 BST

• Venue: Hillsborough Stadium

Match Prediction: Sheffield Wednesday 2-1 Middlesbrough

Sheffield Wednesday are coming off a mixed bag of results, with two losses and two draws in their last four games. They'll be looking to bounce back, because they can hold their own against good teams at times, as indicated by that 2-0 win against Portsmouth. Their style of play has been a bit up and down, but they've got the firepower up front with Brown and Lowe to cause Middlesbrough some problems.

Middlesbrough, on the other hand, have been solid at home but struggled away. Their recent win against Ipswich Town shows they can grind out results when needed. They'll need to be on their toes defensively, as Sheffield Wednesday will be hungry for a win. This could be a tight, tactical battle with both teams looking to exploit any weaknesses.

Sheffield Wednesday's recent form has been inconsistent, with two losses, two draws, and a single win in their last five games. The heavy defeat at home to Coventry City might still be lingering, but they've shown resilience in some games, drawing against Birmingham and QPR. If they can channel that spirit and tighten up at the back, they've got a good chance of getting a result against Middlesbrough.

Recent Championship Results:

• Loss: 1-2 vs Charlton Athletic (A)

• Loss: 0-5 vs Coventry City (H)

• Draw: 2-2 vs Birmingham City (A)

• Draw: 1-1 vs Queens Park Rangers (H)

• Win: 2-0 vs Portsmouth (A)

Middlesbrough have had a decent run lately, with two wins, two draws, and one loss in their last five games. Their home form has been strong, but they'll need to improve their away performances if they want to take something from this game. The win against Ipswich Town will give them confidence, but they'll need to be wary of Sheffield Wednesday's attacking threats.

Recent Championship Results:

• Win: 2-1 vs Ipswich Town (H)
• Loss: 0-1 vs Portsmouth (A)
• Draw: 0-0 vs Stoke City (H)
• Draw: 1-1 vs Southampton (A)
• Win: 2-1 vs West Bromwich Albion (H)

The head-to-head record between Sheffield Wednesday and Middlesbrough has been closely contested recently. In their last five meetings, Middlesbrough have won twice, Sheffield Wednesday once, and there have been two draws. The most recent encounter saw Sheffield Wednesday come out on top with a 2-1 victory, which might give them a psychological edge going into this match.

• Sheffield Wednesday 2-1 Middlesbrough (21 Apr 2025)

• Middlesbrough 3-3 Sheffield Wednesday (26 Dec 2024)

• Middlesbrough 2-0 Sheffield Wednesday (01 Apr 2024)

• Sheffield Wednesday 1-1 Middlesbrough (19 Sep 2023)

• Middlesbrough 3-1 Sheffield Wednesday (24 Apr 2021)

• Guilherme Siqueira (Achilles) - Out

• Pierce Charles (Shoulder) - Doubt

• Ernie Weaver (Foot) - Doubt

• Olaf Kobacki (Groin) - Doubt

• Nathaniel Chalobah (Hamstring) - Doubt

• Di’shon Bernard (Knee) - Doubt

• Seny Dieng (Achilles) - Out

• Riley McGree (Unknown) - Doubt

• Darragh Lenihan (Ankle) - Doubt

• Matt Targett (Hamstring) - Doubt

• George Edmundson (Hamstring) - Doubt

• Predicted lineup: Horvath (GK), Iorfa (DF), Otegbayo (DF), Lowe (DF), Palmer (MF), Valery (MF), Bannan (MF), Ingelsson (MF), Amass (MF), Lowe (AT), Brown (AT)

With Lowe and Brown leading the line, Sheffield Wednesday will look to exploit Middlesbrough's defence with quick, incisive attacks. The midfield trio of Valery, Ingelsson, and Bannan will be crucial in controlling the game's tempo and providing service to the forwards.

• Predicted lineup: Brynn (GK), Brittain (DF), Jones (DF), Fry (DF), Targett (DF), Browne MF), Hackney (MF), Whittaker (MF), Conway (MF), Burgzorg (MF), Strelec (AT)

Middlesbrough's defence, led by Fry and Jones, will need to be solid to keep Sheffield Wednesday's attackers at bay. The midfield combination of Hackney, Conway, Burgzorg, Whittaker, and Browne will be key in dictating play and creating chances for Strelec up top.

• George Brown vs Dael Fry: This will be a crucial battle between Sheffield Wednesday's striker and Middlesbrough's experienced defender.

• Yan Valery vs Hayden Hackney: The duel in midfield between Sheffield Wednesday's Valery and Middlesbrough's Hackney could be pivotal in controlling the game's flow.

• Jamal Lowe (Sheffield Wednesday): Lowe's pace and finishing ability make him a constant threat for Sheffield Wednesday's attack.

• Delano Burgzorg (Middlesbrough): Burgzorg's pace and unpredictability on the left will be vital for Middlesbrough's chances of winning.

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Odds and market details are accurate as of the time of publication.