Tottenham Hotspur vs Atletico Madrid: Champions League RO16 preview, predictions and bet builder tips

• Ladbrokes previews Tottenham vs Atletico Madrid in the Champions League round of 16

• Atletico backed to thrash Spurs again with another haul of goals in North London

• Micky Van de Ven tipped to be shown a card on his return to the starting XI

Ladbrokes brings you an in-depth match preview for Tottenham vs Atletico Madrid including predictions, lineups and expert bet builder tips.

Last week's calamitous 5-2 defeat in Madrid has left Spurs with a real mountain to climb in the Champions League, and despite showing some fight to earn a point at Anfield on Sunday, the Londoners are bang up against it as Diego Simeone's goalscoring machine comes to town.

Below, you'll find our expert Tottenham vs Atletico Madrid bet builder tips - and don't forget to check out our complete round-of-16 preview ahead of this week's second legs.

• Fixture: Tottenham Hotspur vs Atletico Madrid

• Competition: Champions League round of 16 (second leg)

• Date: Wednesday, 18 March, 2026

• Kick-off: 20:00 GMT

• Venue: Tottenham Hotspur Stadium

Our prediction: Tottenham Hotspur 1-4 Atletico Madrid

Atletico Madrid

Our predicted XI (4-4-2): Oblak / Pubill, Le Normand, Hancko, Ruggeri / Simeone, Cardoso, Llorente, Lookman / Alvarez, Griezmann

Tottenham Hotspur

Our predicted XI (4-2-3-1): Vicario / Porro, Romero, Van de Ven, Spence / Palhinha, Gray / Souza, Richarlison, Tel / Solanke

The disastrous performance that Tottenham put in against Atletico Madrid last week has left them with an almost insurmountable deficit to overturn, and in front of their own fans, they have no choice but to attack their Spanish opponents - which spells trouble at the other end.

To go along with our predicted scoreline of 4-1 to the visitors, we're backing over 4.5 goals to be scored as the first pick of our Tottenham vs Atletico Madrid bet builder, with Atletico putting on another masterclass in North London.

Diego Simeone's side have scored 21 goals in their last eight matches across all competitions - including three or more on five separate occasions in that time - and with Tottenham's last clean sheet coming on New Year's Day, we smell goals here.

Dominic Solanke's late strike in the Riyadh Air Metropolitano made it three goals in as many Champions League games for the Englishman, and with our team of experts backing him to start on Wednesday night, we're tipping him to have at least one shot on target.

The striker came on at half time in last week's opening leg, and has shown that he's more than capable of exploiting the space afforded to him by the Atletico backline - which Spurs simply have to do.

Solanke is averaging more than one shot on target per game in the Champions League this season, and with the second leg of this last-16 tie potentially being rather open, we're backing him to have 1+ shots on target again here.

Despite missing Tottenham's hard-fought draw at Anfield through suspension, we're expecting Micky Van de Ven to return to the starting lineup against Atletico - and we're tipping him to pick up a yellow card on a breathless night.

The pacey defender hasn't had a great time of it of late, slipping over to gift Atleti a goal mere days after being sent off in a crucial Premier League match, and we think his struggles could continue here.

With the Dutchman averaging almost two fouls per game in the Champions League, it's no surprise that he already has three UCL bookings to his name, and against such a fluid, ruthless frontline, he's our pick for another card at the Tottenham Hotspur Stadium.

Rounding off our Spurs vs Atletico Madrid preview and bet builder, we're backing the Spaniards to make the most of their huge advantage and romp through to the quarter-finals - putting Tottenham to the sword for the second time in just over a week.

Scoring goals for fun and looking merciless in their first-leg demolition of the Londoners, Atletico are riding the crest of a wave right now, and should have far too much for a bruised, out-of-form, under-pressure Spurs side.

Igor Tudor's hosts will give it a go, and we're backing them to get on the scoresheet, but we're predicting another crushing defeat for the Premier League strugglers, sending them tumbling out of the Champions League with a whimper.

You can bet on each of these markets individually, or combine them to create a Tottenham vs Atletico Madrid Bet Builder.

With Bet Builder+, you can combine your bet with selections not only with other Champions League matches, but also with different sports.

View the latest football odds here.

All odds and markets are correct as of the date of publication.