2026 NFL Odds & Betting
If you are looking to bet on the NFL, Ladbrokes brings together the latest NFL games, betting markets and weekly previews in one place. From the opening week of the regular season through to the Super Bowl, you can explore match betting, point spreads, total points, touchdown scorers, player props and outright markets across the campaign.
NFL 2026 Betting & Odds
The NFL is made up of 32 teams split between the AFC and NFC, with each conference containing four divisions. The regular season determines which teams advance to the playoffs, before the remaining contenders compete for a place in the Super Bowl.
Throughout the season, Ladbrokes offers NFL betting on individual games alongside outright markets covering the Super Bowl, conference winners, division champions and major player awards.
NFL Week 5 Schedule & Latest Odds
Week 4 saw the Patriots hand the Bills their first defeat of the season, while the Chiefs, Vikings and 49ers all maintained their perfect starts. Elsewhere, the Panthers upset the Lions on Sunday Night Football and the Colts comfortably beat the Commanders in London.
Week 5 gets underway with the Buccaneers visiting the Cowboys on Thursday Night Football, before the Eagles face the Jaguars at Tottenham Hotspur Stadium. Sunday’s schedule includes the Bears against the Packers and a key NFC West clash between the 49ers and Seahawks, while the Bills visit the Rams on Monday Night Football.
| Fixture
|
Date & Start Time |
| Dallas Cowboys vs Tampa Bay Buccaneers | Friday, October 9 - 1.15am BST |
| Jacksonville Jaguars vs Philadelphia Eagles | Sunday, October 11 - 2.30pm BST |
| Green Bay Packers vs Chicago Bears | Sunday, October 11 - 6pm BST |
| Miami Dolphins vs Cincinnati Bengals | Sunday, October 11 - 6pm BST |
| New England Patriots vs Las Vegas Raiders |
Sunday, October 11 - 6pm BST |
| New Orleans Saints vs Minnesota Vikings | Sunday, October 11 - 6pm BST |
| New York Jets vs Cleveland Browns | Sunday, October 11 - 6pm BST |
| Pittsburgh Steelers vs Indianapolis Colts | Sunday, October 11 - 6pm BST |
| Tennesee Titans vs Houston Texans | Sunday, October 11 - 6pm BST |
| Washington Commanders vs New York Giants | Sunday, October 11 - 6pm BST |
| Los Angeles Chargers vs Denver Broncos | Sunday, October 11 - 9.05pm BST |
| Arizona Cardinals vs Detroit Lions | Sunday, October 11 - 9.25pm BST |
| Seattle Seahawks vs San Francisco 49ers | Sunday, October 11 - 9.25pm BST |
| Atlanta Falcons vs Baltimore Ravens | Monday, October 12 - 1.20am BST |
| Los Angeles Rams vs Buffalo Bills | Tuesday, October 13 - 1.15am BST |
How do I bet on the NFL?
NFL betting markets allow customers to back more than simply which team will win. Because games can feature clear favourites, Ladbrokes offers point-spread betting in which one side receives a notional advantage or disadvantage. The spread therefore gives bettors an alternative to the standard game winner market.
Total-points betting focuses on whether the combined score will finish above or below a line set for the game. Touchdown markets allow bets on players to score at any point or score the first touchdown, while player props cover individual performances such as passing, rushing and receiving totals.
Ladbrokes also has a dedicated NFL content hub, providing predictions and betting tips throughout the season, including weekly previews, NFL RedZone betting tips and individual analysis of selected games.
More NFL Betting Markets at Ladbrokes
In addition to pre-match NFL odds, Ladbrokes offers In-Play American Football Betting, allowing customers to follow markets as the score and match situation develop.
Explore the latest NFL games, NFL outright betting and NFL specials at Ladbrokes, or follow our weekly previews and NFL betting tips for analysis of the biggest fixtures on the schedule. Create a Ladbrokes account today and check out our range of great promotions.