US Open 2025 Women's Singles final: Aryna Sabalenka vs Amanda Anisimova odds, preview & prediction

• Ladbrokes brings you its odds and predictions for the US Open 2025 women’s singles final.

• The title decider sees defending champion Aryna Sabalenka face eighth seed Amanda Anisimova after both fought back from a set down in the semi-finals.

• In the outright markets, Sabalenka leads the betting ahead of Anisimova, with Jannik Sinner favourite in the Men's Singles.

New York is set for a blockbuster US Open final as defending champion Aryna Sabalenka takes on Amanda Anisimova in the women’s singles title match. Ladbrokes previews this showdown between the world number one and the in-form American, with the latest odds and predictions as both aim to lift the trophy at Flushing Meadows.

Sabalenka is the betting favourite ahead of Saturday's showpiece after another dominant run, but Anisimova leads their head-to-head and will have the fervent backing of the crowd at Arthur Ashe under the lights.

Aryna Sabalenka has looked every inch the number one seed during her run to a second straight US Open final. The Belarusian swept through the early rounds without dropping a set before showing her steel in the last four, overturning an opening-set deficit against Jessica Pegula in a rematch of the 2024 final. Her big serve and heavy groundstrokes have again been the cornerstone of her success in New York, as she chases a fourth Grand Slam.

Amanda has delivered the perfect response to her Wimbledon disappointment, where she failed to win a single game in the final against Iga Swiatek. The 8th-seed stunned the Pole in the quarter-finals to avenge that defeat, then ended Naomi Osaka’s momentum with a gritty three-set victory in the semis. With the New York crowd firmly behind her, the 23-year-old has combined clean ball-striking with new-found composure in pressure moments.

Anisimova holds a 6–3 head-to-head advantage over Sabalenka after extending her lead with victory in their Wimbledon semi-final earlier this summer, which she won in three sets.

The American won their first four meetings before Sabalenka responded with three wins in the next four, including at the 2024 Australian Open and Roland Garros this year. With Anisimova back on top in their most recent Slam clash, this rivalry has swung both ways and promises another intriguing chapter in New York.

Sabalenka's experience on the biggest stage may count, with the Belarusian having won three major titles while Anisimova is still searching for her first.

Anisimova’s response to her Wimbledon humiliation has been hugely impressive and the way she has turned that final defeat into motivation has been one of the stories of the fortnight. Backed by the home crowd and with wins over Swiatek and Osaka already under her belt, she has shown she can handle the pressure of the biggest stages.

Sabalenka, though, remains the more complete player at this stage of her career. The defending champion has the weapons to dictate the rallies, the experience of navigating tight contests and the belief that comes from already lifting the trophy here. The American will have her moments, but the balance of power still lies with Sabalenka to come through and secure back-to-back US Open titles.

Prediction: Aryna Sabalenka to win in three sets

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All odds and markets are correct as of the date of publication.