US Open 2025 odds, favourites & betting guide

Ladbrokes brings you the US Open 2025 odds, favourites and betting guide, with our tournament preview and tips for backing winners in Flushing Meadows.

After an unforgettable summer of tennis, the final Grand Slam of the year takes centre stage in New York, where hard courts and high stakes await the world’s best.

Jannik Sinner is the bookies’ favourite in the Men’s Singles, as he looks to follow up his triumph at Wimbledon on the hard courts by defending his US Open title.

Aryna Sabalenka leads the market in the Women's Singles, with the Belarusian looking to bounce back from recent disappointment at the Majors and retain her US Open crown.

Don't forget to check out Ladbrokes' daily betting tips and predictions for the US Open, updated every day throughout the tournament with our best bets at Flushing Meadows.

The US Open returns for another thrilling fortnight of world-class tennis, electric night sessions and show-stopping drama in the heart of New York City.

As the final Grand Slam of the year, the US Open demands endurance, precision and power on the hard courts of Flushing Meadows. Aggressive baseliners, strong servers and physical athletes tend to thrive under the lights and the pressure.

Jannik Sinner leads the charge in the Men’s Singles after a stellar 2025 season, while Aryna Sabalenka will be targeting redemption in the Women’s draw after falling short in the Slams since her win at Flushing Meadows in 2024.

Mixed Doubles competition: 19-20 August, 2025

Men's & Women's Singles First Round: 24 August, 2025

Women's Singles final: 6 September, 2025

Men's Singles final: 7 September, 2025

Venue: USTA Billie Jean King National Tennis Center, Flushing Meadows, New York

The defending champion Jannik Sinner is the betting favourite to win the 2025 US Open at odds of 8/11. Coming off the back of a victorious Wimbledon, the Italian will aim to continue his dominance on the hard courts that have powered his rise to world number one.

Carlos Alcaraz is next in the running in the Men's Singles at odds of 13/10. After contesting the last two major finals with Sinner, the pair have now shared the last seven Grand Slam titles, and you wouldn't put it past them meeting in the final again. Carlitos won his first major here in 2022.

24-time Grand Slam winner Novak Djokovic follows the two standard-bearers at odds of 11/1. The Serbian is still pushing for that elusive 25th title, but Sinner's dominant semi-final victory appeared to suggest the 38-year-old is finally starting to struggle to keep up with the younger pair.

Felix Auger-Aliassime (33/1) has enjoyed a superb run and reaches the US Open semi-finals for the 2nd time, having knocked out contenders Zverev, Rublev and De Minaur along the way.

Aryna Sabalenka is the favourite to win the Women's Singles at odds of 1/1, as the world number one aims to put recent Grand Slam near misses behind her and defend her US Open title, hoping to return to her success on the hard courts that have made her the player to beat on the WTA Tour.

Two-time US Open winner Naomi Osaka is enjoying her best Grand Slam run in years and has seen her odds slashed to 13/5 after defeating Coco Gauff in the last 16. Whenever the Japanese star has made it past the fourth round of a major, she has gone on to win the tournament.

Amanda Anisimova bounced back from her humiliating Wimbledon final defeat to Iga Swiatek in the perfect fashion by defeating the Polish 2nd seed in the quarter-finals, and is now odds of 7/2 to win the US Open with a matchup against Osaka awaiting her in the semis.

Another home hopeful is Jessica Pegula (15/2), who reached the final here last year but lost to Sabalenka. She faces the same opponent in the semi-finals in 2025, and anything can happen at this stage of the tournament.

Tennis betting at the US Open offers a wide range of markets and opportunities. Some of the most popular include:

Outright winner: Bet on who will lift the trophy under the lights at Flushing Meadowns.

Each-way betting: Get paid out if your player reaches the final – a smart choice in an open draw or with in-form outsiders.

Match betting: Back winners round-by-round across two action-packed weeks in Flushing Meadows.

Set betting: Predict the exact scoreline – perfect when top seeds meet qualifiers or lower-ranked opponents.

In-play betting: With long rallies, momentum shifts and late-night thrillers, live betting at the US Open rewards sharp reactions and tactical insight.

Serve consistency is key: Players with reliable serves and aggressive baseline games often go deep on the hard courts of Flushing Meadows.

Upsets are common: The US Open has a history of early-round shocks, especially under the lights where crowd energy and nerves can play a role.

Night sessions matter: Late matches on Arthur Ashe can produce very different conditions, with cooler temperatures affecting ball speed and bounce.

Strong starters excel: In a best-of-five format for men and best-of-three for women, players who start quickly can take control and build scoreboard pressure early.

Hard-court form holds up: Results from the North American swing, including Cincinnati and Toronto, often point to players peaking at the right time.

View the latest tennis odds.

All odds and markets are correct as of the date of publication.