Atletico Madrid vs Manchester United predictions: Champions League tips & 11/1 Bet Builder

Manchester United return to Champions League action in desperate need of a pick-me-up, but they arrive in Spain as underdogs against Diego Simeone's Atletico Madrid - who have never lost to the Red Devils.

Michael Carrick's side are winless in four across all competitions, conceding late to drop points against Spurs on Saturday, and face an Atletico side with four wins on the bounce (including a derby-day victory over Real Madrid) - but under the lights of the Metropolitano, can the out-of-form visitors spring a surprise?

Below, you can explore our detailed Atletico Madrid vs Man United betting preview, with expert predictions, Bet Builder tips, and the latest odds.

Atletico Madrid vs Man United match details

• Fixture: Atletico Madrid vs Manchester United

• Competition: Champions League (league phase)

• Date: Tuesday, October 13, 2026

• Kick-off: 20:00 BST

• Venue: Riyadh Air Metropolitano

• UK TV: Prime Video

Our prediction: Atletico Madrid 2-1 Man United

Atletico Madrid vs Man United predicted lineups

Atletico Madrid

Our predicted XI (4-4-2): Oblak / Llorente, Romero, Hancko, Grimaldo / Simeone, Cardoso, Koke, Baena / Lee, Alvarez

Man United

Our predicted XI (4-2-3-1): Lammens / Dalot, Maguire, Martinez, Shaw / Tielemans, Mainoo / Amad, Fernandes, Cunha / Mbeumo

Atletico Madrid vs Man United Bet Builder

Ladbrokes share their Atletico Madrid vs Manchester United Bet Builder, which is coming in at 11/1 at the time of writing.

• Leg 1 - Atletico Madrid to score the first goal

• Leg 2 - Alex Baena 1+ shots on target

• Leg 3 - Diogo Dalot to commit 2+ fouls

• Leg 4 - Atletico Madrid to win

Atletico Madrid to score the first goal

With Atletico Madrid looking for a fifth straight win - something Man United famously haven't managed for more than two years now - we're expecting the hosts to come out of the blocks flying on Tuesday night, hitting the visitors early with the first goal of the game. Diego Simeone's side have opened the scoring in each of their last five matches, and have actually done so in eight of their nine games across all competitions this term, and with United struggling for confidence, this one seems a strong first pick for our UCL Bet Builder.

Alex Baena 1+ shots on target

One of Atletico's main creative outlets, Alex Baena has also shown his eye for goal with four LaLiga strikes already this term, and against a bruised, breachable Man United backline, we're tipping the Spaniard to have an effort on target here. The 25-year-old is averaging well over a shot on target per 90 in the league this season, and had two attempts in his side's Champions League defeat at Anfield in September, so he's odds-on to test Senne Lammens this time around.

Diogo Dalot to commit 2+ fouls

Having only played half an hour against Tottenham at the weekend, we're expecting Diogo Dalot to return to the starting XI for this UCL clash, but against a series of tricky forwards, our experts are tipping him to commit at least two fouls. The Portugal international is conceding almost two free kicks per 90 in the Premier League, and has already picked up two bookings, so as he looks to impose himself on the Atletico frontline, Dalot seems a smart selection in the fouls market.

Atletico Madrid to win

Four wins in a row have Simeone's hosts priced as firm favourites to take all three points here, and with Man Utd arriving in the midst of a mini crisis, we can only see one winner. One league win since May has put Michael Carrick under serious pressure, with the Englishman now tipped to lose his job before any other Premier League boss, and against such an experienced, resolute outfit, we're tipping United to fall to yet another defeat in the Spanish capital.

View the latest Champions League odds here.

View the latest football odds here.

All odds and markets are correct as of the date of publication.