The Premier League champions are five points clear of Brighton in sixth having played a game fewer and a win would keep them within touching distance of fourth-placed Aston Villa. Three points are far from guaranteed, however, as they come up against an Eagles side they have already lost three times to this season, including a 3-0 defeat at Anfield in the Carabao Cup in September.
Palace have also hit a decent run of form during the back end of the season with an eight-match unbeaten run which has seen them climb towards the top half and reach the Conference League semi-finals.
Ahead of what should be an exciting match on Merseyside, check out our in-depth preview including lineups, predictions and tips for your bet builder. Liverpool are favourites for the game at 1/2, with a Palace win priced at 19/4 and a draw 18/5.
A man who will be relishing his trip to Anfield is Ismaila Sarr, who has made scoring against Liverpool something of a habit during his time in the Premier League, both at Palace and stretching back to his Watford days.
The Senegal international has seven goals in nine previous games against the Reds, which include goals in each of the three meetings with them this season in the Community Shield, Premier League and Carabao Cup.
Seventeen goals this term in all competitions is already his best tally in a Palace shirt and that's why we think he looks primed to cause more misery for the Liverpool faithful in this important game.
Mohamed Salah to have 2+ shots on target
Another man who has hit form at the right time is outgoing talisman Mohamed Salah, who has netted in each of his last three Premier League appearances including the opener in the Merseyside derby last weekend.
The legendary Egyptian has nine goals in 18 previous games against Palace and will hope to continue his Liverpool swansong by firing them into the Champions League this season. As a result, we think he is good value to have at least two shots on target.
Both teams to score
With Liverpool quietly going about their business during the run-in and given Palace's good record against the Reds, we're tipping both nets to be breached on Saturday afternoon.
Around 63% of Liverpool's games this season have seen both teams find the net with the same outcome for exactly half of the Eagles' games. After drawing a blank against West Ham, we're predicting Oliver Glasner's men to get back on the scoresheet.
Liverpool to win or draw
Finally, we're tipping a Liverpool win or draw in a double-chance bet. While Palace still have a European campaign to contend with, the Premier League is the sole focus for Liverpool and that's why we think they'll have the upper hand.
That said, Palace have proved a bogey team for the Reds on many occasions and they'll arrive in the North-West in confident mood, so allowing for the outcome of Palace getting more points off them covers your bases nicely in this bet builder.
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When is Liverpool vs Crystal Palace?
Liverpool vs Crystal Palace takes place on Saturday, April 25, 2026, with kick-off scheduled for 3pm UK time.
Where can I watch Liverpool vs Crystal Palace?
Liverpool vs Crystal Palace is not available to watch on TV in the UK.
Can you bet on Liverpool vs Crystal Palace?
Ladbrokes are offering customers the chance to bet on a number of Liverpool vs Crystal Palace markets, including match result, both teams to score and goalscorers.
