NFL 2025: Super Bowl odds, MVP favourites and playoff predictions

Ladbrokes brings you the complete NFL 2025 season guide, packed with Super Bowl odds, MVP favourites and playoff predictions.

With six weeks in the books and the season already throwing up shocks and surges, we break down the frontrunners, climbers and best-value outsiders across every major market.

From outright Super Bowl picks and MVP hopefuls to division odds and more, follow our guide for the latest betting insights updated throughout the season. And for those new to the NFL, don't worry - we've got you covered in our beginner's guide to betting on the NFL.

The race for Super Bowl LX is wide open at the start of the 2025 season, with no single team pulling clear in the market. The Buffalo Bills remain at the front of the market at 11/2, despite stalling after their fast start. They still carry the most complete roster on paper, but recent defeats have tightened the field behind them.

The Kansas City Chiefs (6/1) have climbed back into contention after a statement win over Detroit, reminding the league they’re never far from the conversation, even without their usual fluency on offense. The Detroit Lions now sit at 15/2, with injuries beginning to bite, but their win in Baltimore still carries weight in the outright picture. Division rivals Green Bay Packers follow at 8/1, with the Micah Parsons trade yet to fully translate into dominance. Defending champions Philadelphia Eagles are also 8/1, but inconsistent form and growing scrutiny around their attack have cooled momentum for now.

The LA Rams (12/1) and Denver Broncos (16/1) headline the cluster of contenders beneath them. Sean McVay’s side continue to look dangerous on both sides of the ball, while Denver have built a solid foundation with defense and a reliable ground game. The Tampa Bay Buccaneers (16/1) are emerging as a serious threat in the NFC, with Baker Mayfield’s resurgence keeping them firmly in the hunt. The Indianapolis Colts (18/1) have also played themselves into contention after a 5–1 start behind Daniel Jones.

AFC heavyweights Baltimore Ravens have drifted to 20/1 after a shocking 1-5 start, hampered by injuries and defensive frailties. The San Francisco 49ers are also 20/1 and going through an injury crisis of their own, but are still viewed as dangerous if they get healthy.

The NFL MVP race looks just as competitive as the Super Bowl market, but two clear favourites have emerged, with Josh Allen (9/5) and Patrick Mahomes (2/1) pulling clear at the top of the market.

The biggest mover is Baker Mayfield (3/1), who has vaulted into serious contention after a stunning 5–1 start with Tampa Bay. He’s engineered four game-winning drives already this season and has become a genuine storyline in the awards race.

Behind the leading trio, Rams QB Matthew Stafford (10/1) and Detroit's Jared Goff (14/1) have both stayed in the conversation as they lead two of the league's most exciting offenses.

Jordan Love (14/1) and Justin Herbert (16/1) have cooled slightly after early-season momentum, but both remain firmly in the hunt if their teams stay in the playoff picture. Drake Maye (20/1) has played himself into dark-horse territory thanks to New England’s resurgence and his growing poise in big games.

Among the non-quarterbacks, Christian McCaffrey (80/1) and Bijan Robinson (100/1) are the shortest-priced skill players but would need historic production to overhaul the quarterbacks dominating the race.

Here’s how the individual AFC and NFC divisions shape up heading into the season. The winner of each of the eight divisions is guaranteed a playoff spot, with three additional wildcard spots granted to each conference.

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All odds and markets are correct as of the date of publication.