NFL Week 1 odds, preview and predictions: Eagles vs Cowboys, Chargers vs Chiefs, Packers vs Lions and more

Ladbrokes brings you the complete NFL Week 1 preview, packed with the full schedule, odds, predictions and the biggest storylines from the opening slate of fixtures.

The new season kicks off with a bang, featuring heavyweight clashes, divisional rivalries and primetime drama as all 32 teams return to action. From the Eagles’ title defence to blockbuster AFC battles, Week 1 promises fireworks right from the start.

With odds and betting insights for every matchup, plus outright markets on the Super Bowl and NFL MVP odds, we’ve got Week 1 covered with everything you need to follow the action.

For the season’s bigger picture visit our NFL 2025 season preview, and if you're new to the sport, start with our beginner’s guide to betting on the NFL.

• Lincoln Financial Field, Philadelphia, Friday 1.20am

• Eagles -7.5 point favourites, Over/Under 47 points

The NFL season opens with a divisional clash as the defending champions Philadelphia Eagles meet the Dallas Cowboys. Jalen Hurts and Saquon Barkley lead the Eagles again after their Super Bowl triumph in New Orleans, while Dak Prescott must rally a Cowboys side adjusting to life without Micah Parsons following his seismic trade to Green Bay.

Pick: Eagles

• Corinthians Arena, Sao Paulo, Saturday 1am

• Chiefs -2.5 point favourites, Over/Under 46 Points

A Friday night kickoff in São Paulo sees the Kansas City Chiefs face the Los Angeles Chargers. Patrick Mahomes begins the campaign aiming to rebound from that resounding Super Bowl defeat, while Justin Herbert looks to push on in his second year under Jim Harbaugh after reaching the playoffs last year.

Pick: Chiefs

• Mercedes-Benz Stadium, Atlanta, Sunday 6pm

• Buccaneers -1.5 point favourites, Over/Under 47.5 Points

In the NFC South, the Atlanta Falcons host the Tampa Bay Buccaneers. Michael Penix Jr starts his second season at quarterback after Kirk Cousins failed to establish himself in Atlanta, while the Bucs seek a fifth straight division title with Baker Mayfield and Mike Evans still a reliable connection.

Pick: Buccaneers

• Huntington Bank Field, Cleveland, Sunday 6pm

• Bengals -5.5 point favourites, Over/Under 47 Points

An early AFC North battle sees the Cincinnati Bengals meet the Cleveland Browns. Joe Burrow, Ja’Marr Chase and Tee Higgins headline one of the NFL’s most dangerous offenses, while Myles Garrett anchors a Browns defense capable of disrupting any passing attack.

Pick: Bengals

• Lucas Oil Stadium, Indianapolis, Sunday 6pm

• Colts -1.5 point favourites, Over/Under 47 Points

At Lucas Oil Stadium, the Indianapolis Colts face the Miami Dolphins. Daniel Jones is confirmed as the starter ahead of Anthony Richardson, while Miami’s hopes hinge on the availability of Tyreek Hill and Tua Tagovailoa, both listed as questionable to open the year.

Pick: Dolphins

• Everbank Stadium, Jacksonville, Sunday 6pm

• Jaguars -3 point favourites, Over/Under 46.5 Points

In a NFC South–AFC South crossover, the Jacksonville Jaguars meet the Carolina Panthers. New Jags head coach Liam Coen begins his tenure with the added spark of rookie Travis Hunter, a rare two-way talent on offense and defense. Panthers QB Bryce Young enters 2025 off the back of an encouraging finish to last season, after being benched earlier in the season.

Pick: Jaguars

• Gillette Stadium, Foxborough, Sunday 6pm

• Patriots -2.5 point favourites, Over/Under 44 Points

Coaching changes headline this one as the New England Patriots host the Las Vegas Raiders. Mike Vrabel takes charge in New England for the first time with QB Drake Maye attempting to make strides in his second year, while the Raiders have reunited Pete Carroll and Geno Smith in an effort to stabilise the franchise after inconsistency last season.

Pick: Patriots

• Caesars Superdome, New Orleans, Sunday 6pm

• Cardinals -4.5 point favourites, Over/Under 43 Points

At the Superdome, the New Orleans Saints face the Arizona Cardinals. The Saints enter 2025 projected among the frontrunners for the number one pick in the draft, while Jonathan Gannon’s Cardinals look to take the next step with Kyler Murray healthy and the defense strengthened through offseason additions.

Pick: Cardinals

• MetLife Stadium, New Jersey, Sunday 6pm

• Steelers -3 point favourites, Over/Under 38.5 Points

In the AFC, the New York Jets meet the Pittsburgh Steelers. Aaron Rodgers starts against his former team in a storyline-laden opener, with new Jets head coach Aaron Glenn beginning his tenure by moving on from him at quarterback. Pittsburgh rely on a defense that remains among the league’s toughest units, and Mike Tomlin's long established streak without a losing record.

Pick: Jets

• Northwest Stadium, Maryland, Sunday 6pm

• Commanders -6 point favourites, Over/Under 46 Points

At Northwest Stadium, the Washington Commanders host the New York Giants in a divisional matchup. Offensive Rookie of the Year Jayden Daniels begins his second season after guiding the Commanders to the NFC title game, while New York’s defense is boosted by the arrival of #3 pick Abdul Carter, a potential candidate for Defensive Rookie of the Year.

Pick: Commanders

• Empower Field at Mile High, Denver, Sunday 9.05 pm

• Broncos -7 point favourites, Over/Under 42.5 Points

The late RedZone slate features Sean Payton's Denver Broncos against the Tennessee Titans. Denver look to build on a playoff run powered by rookie quarterback Bo Nix, with defensive reinforcements added in the offseason. Tennessee begin the Cam Ward era as the number one pick debuts under centre.

Pick: Broncos

• Lumen Field, Seattle, Sunday 9.05pm

• 49ers -1.5 point favourites, Over/Under 43.5 Points

A fierce NFC West rivalry sees the San Francisco 49ers face the Seattle Seahawks. The 49ers seek to rebound after a 6–11 campaign with Christian McCaffrey healthy, while Seattle enter a new era following the departures of Geno Smith, DK Metcalf and Tyler Lockett.

Pick: 49ers

• Lambeau Field, Green Bay, Sunday 9.25pm

• Packers -1.5 point favourites, Over/Under 47.5 Points

In a blockbuster NFC North clash, the Green Bay Packers take on the Detroit Lions. Jordan Love leads Green Bay with new signing Micah Parsons anchoring the defense, while Detroit adjust after both coordinators left for head coaching roles despite consecutive playoff runs.

Pick: Lions

• SoFi Stadium, Los Angeles, Sunday 9.25pm

• Rams -2.5 point favourites, Over/Under 44.5 Points

At SoFi Stadium, the Los Angeles Rams host the Houston Texans. The Rams replace Cooper Kupp with Davante Adams and field a young, improving defense. Houston return to the playoffs last season despite uneven form, with hopes that C.J. Stroud can rediscover his rookie-year level on offense.

Pick: Rams

• Highmark Stadium, Buffalo, Monday 1.20am

• Bills -1.5 point favourites, Over/Under 49.5 Points

This Sunday night primetime showdown pits the Buffalo Bills against the Baltimore Ravens. It's a rematch of last season’s divisional playoff, won by Buffalo, and brings together two of the joint Super Bowl favourites, as well as MVP frontrunners Josh Allen and Lamar Jackson.

Pick: Ravens

• Soldier Field, Chicago, Tuesday 1.15am

• Vikings -1.5 point favourites, Over/Under 44 Points

Week 1 closes in the NFC North as the Chicago Bears take on the Minnesota Vikings on Monday night. Caleb Williams starts his second year in Chicago with the arrival of new head coach Ben Johnson, while Minnesota turn to 2024 first-round pick J.J. McCarthy after Sam Darnold’s impressive campaign.

Pick: Vikings

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All odds and markets are correct as of the date of publication.