The race for Super Bowl LX is wide open at the start of the 2025 season, with no single team pulling clear in the market. The Buffalo Bills have fallen to fourth-favourites at 15/2. That comes as they've stalled after their fast start. The Bills still carry the most complete roster on paper, but recent defeats have seen them lose their spot as front-runners.
The Kansas City Chiefs (9/2) have climbed to the top of the betting market, with a recent win over Detroit reminding the league they’re never far from the conversation, even without their usual fluency on offense. The Detroit Lions now sit at 6/1, with injuries beginning to bite, but their performances still see them warrant their spot as second-favourites.
Division rivals Green Bay Packers follow at 7/1, with the Micah Parsons trade yet to fully translate into dominance. Defending champions Philadelphia Eagles are 9/1, with inconsistent form and growing scrutiny around their attack cooling momentum for now.
The LA Rams (10/1) and Indianapolis Colts (11/1) headline the cluster of contenders beneath them. Sean McVay’s Rams continuing to look dangerous on both sides of the ball. AFC heavyweights Baltimore Ravens had drifted to 20/1 after a shocking 1-5 start, hampered by injuries and defensive frailties, but are now at 16/1.
The Tampa Bay Buccaneers (25/1) were emerging as a serious threat in the NFC, but have seen their odds fall in the final few days of October. The San Francisco 49ers are also 20/1 and going through an injury crisis of their own, but are still viewed as dangerous if they get healthy.
