Liverpool vs Atletico Madrid predictions: Champions League tips & 17/1 Bet Builder

Champions League football returns to Anfield on Wednesday night as Liverpool welcome familiar foes Atletico Madrid back to Merseyside, not even a year since their thrilling encounter in last season's league phase.

The Reds won 3-2 that night, and after finally picking up their first win of the 2026/27 Premier League season on Friday, Andoni Iraola's side look primed to kickstart their UCL campaign in perfect fashion - with the hosts arriving as odds-on favourites to claim all three points.

It'll be far from easy, with Atletico always bringing the fight, so see what our experts think will happen in this Liverpool vs Atletico Madrid betting preview, with Bet Builder tips, predictions, and live odds.

Liverpool vs Atletico Madrid match details

• Fixture: Liverpool vs Atletico Madrid

• Competition: Champions League (league phase)

• Date: Wednesday, September 9, 2026

• Kick-off: 20:00 BST

• Venue: Anfield

• TV Channel: TNT Sports / HBO Max

Our prediction: Liverpool 3-2 Atletico Madrid

Liverpool vs Atletico Madrid predicted lineups

Liverpool

Our predicted XI (4-2-3-1): Alisson / Szoboszlai, Jacquet, van Dijk, Kerkez / Gravenberch, Mac Allister / Munoz, Wirtz, Gakpo / Isak

Atletico Madrid

Our predicted XI (4-4-2): Oblak / Llorente, Pubill, Hancko, Grimaldo / Simeone, Barrios, Hjulmand, Lookman / Lee, Baena

Liverpool vs Atletico Madrid Bet Builder

Ladbrokes share their Liverpool vs Atletico Madrid Bet Builder, which is coming in at 17/1 at the time of writing.

• Leg 1 - Over 3.5 goals to be scored

• Leg 2 - Alexander Isak 2+ shots on target

• Leg 3 - Marc Pubill to be shown a card

• Leg 4 - Liverpool to win

Over 3.5 goals to be scored

With last season's thriller still fresh in the memory, our experts are predicting (and hoping for) another blockbuster Champions League night under the lights at Anfield, with over 3.5 goals being scored in the match. Liverpool have scored two goals in each of their three Premier League games this season, while Atletico have notched seven in their last four, and with just one clean sheet apiece so far this term, both teams will be ready to pounce.

Alexander Isak 2+ shots on target

Alexander Isak grabbed his first Liverpool brace against Ipswich last week, taking his tally for the season to three already, and with the Swede still hunting for his first Champions League goal for the club, we're tipping him to test Jan Oblak at least twice. Isak is averaging almost two shots on target per 90 this season, and appears to be growing in confidence by the week, so as he continues to lead the line for Andoni Iraola's men, he'll be provided with plenty of chances.

Marc Pubill to be shown a card

If there's one thing you can expect from a Diego Simeone side, it's relentless intensity, and we think that'll be epitomised by defender Marc Pubill - who Ladbrokes are tipping to pick up a card. The 23-year-old is committing just under two fouls a game this season, and has already been booked once in La Liga, so on one of the biggest nights of his young career, we're expecting the electric attacking threat of Liverpool to catch him out.

Liverpool to win

After finally winning in the league last week, Liverpool will be desperate to make it back-to-back victories under Andoni Iraola, giving the new boss his first Anfield win - and that's exactly what we're expecting to happen. Liverpool have actually won all of the last three meetings between these two sides, scoring eight goals in the process, and with Atleti arriving off the back of a 3-0 defeat to Athletic Club, the visitors will be bang up against it in front of a raucous crowd.

View the latest Champions League odds here.

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All odds and markets are correct as of the date of publication.