Manchester United vs AS Roma predictions: Champions League tips & 5/1 Bet Builder

Yet another Premier League defeat on Saturday extended Manchester United's winless run to nine games in all competitions, and things don't get any easier as they welcome an in-form Roma side to Old Trafford in an enticing Champions League tie.

The Serie A hopefuls are still unbeaten domestically, and their only defeat in any competition came against Jose Mourinho's seemingly unstoppable Real Madrid, so they'll be more than ready to pile further pressure on Michael Carrick and Co here - but with Man United priced as the bookies' favourites, can the Red Devils finally regain that winning feeling?

Below, readers can dive into our Man United vs Roma betting preview, with expert predictions, Bet Builder tips, and live odds ahead of Tuesday night's showdown.

Man United vs Roma match details

• Fixture: Manchester United vs AS Roma

• Competition: Champions League (league phase)

• Date: Tuesday, November 3, 2026

• Kick-off: 20:00 GMT

• Venue: Old Trafford

• Where to watch / UK TV: Prime Video

Our prediction: Man United 1-3 Roma

Man United vs Roma predicted lineups

Man United

Our predicted XI (4-2-3-1): Lammens / Yoro, Maguire, Martinez, Dalot / Baleba, Tielemans / Mbeumo, Fernandes, Mount / Cunha

Roma

Our predicted XI (3-4-2-1): Gollini / Mancini, N'Dicka, Hermoso / Wesley, de Roon, Cristante, Molina / Soule, Mora / Malen

Man United vs Roma Bet Builder

Ladbrokes share their Manchester United vs Roma Bet Builder, which is coming in at 5/1 at the time of writing.

• Leg 1 - Over 2.5 goals to be scored

• Leg 2 - Donyell Malen 1+ shots on target

• Leg 3 - Leny Yoro to commit 1+ fouls

• Leg 4 - Roma to win

Over 2.5 goals to be scored

Each of Roma's last four matches have featured at least four goals, with the Italians scoring three or more on every occasion, and with Man United currently shipping goals in every competition (conceding nine across their last three), it would be a surprise if we didn't see plenty of chances. The hosts will definitely threaten themselves too, with 10 shots on target in their last two games, and with Roma's defence also leaking of late (seven goals conceded in three games), we're backing the attacks to come out on top at Old Trafford.

Donyell Malen 1+ shots on target

Donyell Malen has been a revelation since swapping the Premier League for Serie A, and with five goals in his last five games, we're tipping the Dutchman to be Roma's main threat once again - having at least one shot on target. The 27-year-old has already bagged 11 goals in all competitions this term, and with a Champions League average of almost five shots per 90 - with roughly half of them hitting the target - he's a strong pick to test Senne Lammens in the United net.

Leny Yoro to commit 1+ fouls

Defender Leny Yoro has been deployed as a right-back in recent weeks, and with our experts predicting a similar story here, we're backing the young Frenchman to commit at least one foul. The 20-year-old is committing over 2.5 fouls per 90 in the Champions League this season, already picking up a red card against Atletico Madrid in Gameweek 2, and on what could be another frustrating evening for the hosts, the out-of-position full-back seems a strong pick for a foul here.

Roma to win

The form guide could hardly paint a starker picture ahead of this one, with Man United winless in nine and Roma unbeaten in five - with just one defeat in 13 games - so it's the high-flying visitors who we're tipping to take the points. The Serie A side have scored more goals in their last three league games than United have managed in the Premier League all season, and with four defeats in five for the Red Devils, confidence couldn't be much lower - so yet another defeat for Man Utd is our final selection.

View the latest Champions League odds here.

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All odds and markets are correct as of the date of publication.