Slavia Prague vs Arsenal predictions: Champions League tips & 9/1 Bet Builder

A first win at Anfield in 14 years has proved Arsenal's credentials once again as one of Europe's very best, and their hunt for that elusive Champions League trophy continues at the Fortuna Arena on Wednesday night, as the Gunners take on Czech champions Slavia Prague.

Mikel Arteta's men remain unbeaten in this season's UCL, and haven't actually lost a league-phase match since November 2024, so they arrive as overwhelming favourites to get the better of their winless hosts in Gameweek 4 - but can Slavia Prague upset the odds and rock the champions of England?

Below, you can explore our Slavia Prague vs Arsenal betting preview, with expert predictions, Bet Builder tips, and the latest odds.

Slavia Prague vs Arsenal match details

• Fixture: Slavia Prague vs Arsenal

• Competition: Champions League (league phase)

• Date: Wednesday, November 4, 2026

• Kick-off: 20:00 GMT

• Venue: Fortuna Arena

• Where to watch / UK TV: TNT Sports / HBO Max

Our prediction: Slavia Prague 0-3 Arsenal

Slavia Prague vs Arsenal predicted lineups

Slavia Prague

Our predicted XI (3-4-2-1): Domchak / Holes, Zima, N'Guessan / Vicek, Moses, Nowak, Kubiak / Ayaosi, Sulemain / Sturm

Arsenal

Our predicted XI (4-2-3-1): Raya / White, Mosquera, Gabriel, Hincapie / Lewis-Skelly, Rice / Madueke, Odegaard, Eze / Gyokeres

Slavia Prague vs Arsenal Bet Builder

Ladbrokes share their Slavia Prague vs Arsenal Bet Builder, which is coming in at 9/1 at the time of writing.

• Leg 1 - Slavia Prague to fail to score

• Leg 2 - Martin Odegaard 1+ shots on target

• Leg 3 - Wiktor Nowak to be shown a card

• Leg 4 - Arsenal to win

Slavia Prague to fail to score

Another clean sheet on Sunday was a fourth in six games for Arsenal, and with two already in this season's Champions League, it's almost a surprise when the Gunners do concede - so against one of the competition's lowest scorers, we're predicting another robust defensive display.

Mikel Arteta's side won at Anfield without conceding a single shot on target at the weekend, and with David Raya only being forced into six saves across Arsenal's opening three UCL matches (three of which came against Bayern Munich), we can't see him being beaten here - particularly with William Saliba also returning to the squad for this trip to Czechia.

Martin Odegaard 1+ shots on target

After making the mistake of leaving his captain out of the starting XI for Arsenal's trip to Fleetwood in last week's Carabao Cup humiliation, Mikel Arteta will surely be putting Martin Odegaard at the heart of his side for this trip to Czechia, and we're tipping the Norwegian to have at least one shot on target.

With an average of almost two shots per 90 in both the Premier League and Champions League this term, it's little wonder that Odegaard has already quadrupled his goal tally from last season, and against what is likely to be a low block, shots from outside the area could well be his approach.

Wiktor Nowak to be shown a card

Wherever he plays (which seems to alter by the week), Wiktor Nowak is always heavily involved in Slavia Prague's play, and with our experts predicting him to line up in midfield on Wednesday night, we're tipping him to be shown a card.

The 22-year-old is committing almost two fouls per 90 in the Czech First League, and has already picked up four bookings across all competitions this term, so on a night where he's likely to have plenty of defending to do against one of the Champions League outright favourites, he looks primed to make his mark one way or another.

Arsenal to win

Arsenal rarely make hard work of league-phase matches in the Champions League, and actually visited the Fortuna Arena a year ago to the day, coming away with a routine 3-0 victory - and we're expecting history to repeat itself this time around.

The Gunners have won their two previous visits to Prague without conceding a goal, and despite the hosts coming into this having suffered just one defeat in their last nine games, the Gunners have only lost once inside 90 minutes since April - so the Premier League champions should be far too strong.

View the latest Champions League odds here.

View the latest football odds here.

All odds and markets are correct as of the date of publication.