Ladbrokes brings you the complete NFL Week 4 odds, preview and predictions as the season’s first month concludes with heavyweight clashes, headline storylines and playoff implications already emerging. This week’s slate is led by Chiefs vs Ravens, a potential AFC Championship preview, while Micah Parsons makes his highly anticipated return to Dallas with the Green Bay Packers.
With odds and betting insights for every matchup, plus key markets across moneyline, totals and player props, we’ve got Week 4 covered with everything you need to follow the action. For the season-long picture visit our NFL 2025 odds hub, check the latest Super Bowl odds and NFL MVP odds, or get started with our beginner’s guide to betting on the NFL.

State Farm Stadium, Glendale, Friday 1.15am
Seahawks -1.5 point favourites, Over/Under 43.5 points
Croke Park, Dublin, Sunday 2.30pm
Vikings -2.5 point favourites, Over/Under 41.5 points
Mercedes-Benz Stadium, Atlanta, Sunday 6pm
Commanders -2.5 point favourites, Over/Under 45.5 points
Highmark Stadium, Buffalo, Sunday 6pm
Bills -16.5 point favourites, Over/Under 47.5 points
Ford Field, Detroit, Sunday 6pm
Lions -9.5 point favourites, Over/Under 45.5 points
NRG Stadium, Houston, Sunday 6pm
Texans -7 point favourites, Over/Under 39.5 points
Gillette Stadium, Foxborough, Sunday 6pm
Patriots -4.5 point favourites, Over/Under 43.5 points
MetLife Stadium, New Jersey, Sunday 6pm
Chargers -5.5 point favourites, Over/Under 44 points
Raymond James Stadium, Tampa, Sunday 6pm
Eagles -3.5 point favourites, Over/Under 43.5 points
SoFi Stadium, Los Angeles, Sunday 9.05pm
Rams -3.5 point favourites, Over/Under 49 points
Levi's Stadium, Santa Clara, Sunday 9.05pm
49ers -3.5 point favourites, Over/Under 47 points
Arrowhead Stadium, Kansas City, Sunday 9.25pm
Ravens -2.5 point favourites, Over/Under 48.5 points
Allegiant Stadium, Las Vegas, Sunday 9.25pm
Bears -1 point favourites, Over/Under 47.5 points
AT&T Stadium, Arlington, Monday 1.20am
Packers -7 point favourites, Over/Under 47.5 points
Hard Rock Stadium, Miami, Tuesday 12.15am
Dolphins -2.5 point favourites, Over/Under 45.5 points
Mile High, Denver, Monday 1.15am
Broncos -7.5 point favourites, Over/Under 44 points
All odds and markets are correct as of the date of publication.