It's also a big game for Spurs as they welcome new interim manager Igor Tudor in the dugout for the first time since replacing Thomas Frank - so Arsenal are set to be treated to a cauldron of an atmosphere as the hosts look to land a damaging blow on their rivals.
Check out our in-depth preview for the North London derby, including lineups, predictions and expert tips for your Spurs vs Arsenal bet builder.
Our predicted XI (3-4-2-1): Vicario / Palhinha, Dragusin, Van de Ven / Gray, Gallagher, Sarr, Spence / Kolo Muani, Simons / Solanke
Arsenal
Our predicted XI (4-3-3): Raya / Timber, Saliba, Gabriel, Hincapie / Zubimendi, Rice, Odegaard / Saka, Havertz, Martinelli
Tottenham vs Arsenal bet builder tips
Bukayo Saka to score anytime
Bukayo Saka is an old hand when it comes to the North London derby these days and he's got a good record against Arsenal's bitter rivals, too, with eight goal contributions in his last nine appearances in this fixture.
The England man has assumed a new No10 role in recent games and it paid dividends with the opener against Wolves, albeit he looks set to shift back to the right-hand side for this game. We reckon he'll shake off an injury problem in that game and celebrate his new contract with another NLD goal.
Joao Palhinha to be shown a card
The cards markets are always a favourite for derbies and this one is no different, with Spurs likely to make it a hostile atmosphere for the visit of their neighbours and start of Tudor's reign in style.
With usual culprit Cristian Romero suspended for a red card vs Manchester United, we're backing Joao Palhinha to get himself into the referee's book. The midfielder is a feisty character and is not afraid to put his foot in and assert his authority. With six yellows already this term, another feels more than feasible.
Both teams to score
Rewind even two weeks and you'd automatically think this game would be a procession for Arsenal against their struggling opponents, but events on both sides have shifted the narrative slightly and the game does not feel the foregone conclusion it once did.
Wolves showed that Arsenal are far from impenetrable and with Spurs hardly excelling in defence, this should be a good game for the neutral with both teams finding the net.
Arsenal to win
Our final pick is for Arsenal to ignore the noise and grab an important win in the North London derby.
The Gunners will be desperate to avoid the weekend ending with their lead just two points and, given it's a tough first game for Tudor to start his reign, we think the visitors will do enough for the three points.
You can bet on each of these markets individually, or combine them to create a Spurs vs Arsenal Bet Builder.
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We may be tipping Arsenal to win, but former Spurs midfielder Jake Livermore is backing his old team to grab a shock victory on Sunday, while he also shared his thoughts on who their next manager should be in an exclusive interview with Ladbrokes.
When is Tottenham vs Arsenal?
Tottenham vs Arsenal takes place on Sunday, February 22, 2026 with kick-off scheduled for 4:30pm UK time.
What channel is Spurs vs Arsenal on?
Spurs vs Arsenal will be shown live on TNT Sports and Discovery+.
Can you bet on Spurs vs Arsenal?
Ladbrokes are offering customers the chance to bet on a number of Spurs vs Arsenal markets, including match result, both teams to score and goalscorers.
