NFL Week 4 odds, preview and predictions: Chiefs vs Ravens, Parsons returns to Dallas & more

Ladbrokes brings you the complete NFL Week 4 odds, preview and predictions as the season’s first month concludes with heavyweight clashes, headline storylines and playoff implications already emerging. This week’s slate is led by Chiefs vs Ravens, a potential AFC Championship preview, while Micah Parsons makes his highly anticipated return to Dallas with the Green Bay Packers.

With odds and betting insights for every matchup, plus key markets across moneyline, totals and player props, we’ve got Week 4 covered with everything you need to follow the action. For the season-long picture visit our NFL 2025 odds hub, check the latest Super Bowl odds and NFL MVP odds, or get started with our beginner’s guide to betting on the NFL.

• State Farm Stadium, Glendale, Friday 1.15am

• Seahawks -1.5 point favourites, Over/Under 43.5 points

• Croke Park, Dublin, Sunday 2.30pm

• Vikings -2.5 point favourites, Over/Under 41.5 points

• Mercedes-Benz Stadium, Atlanta, Sunday 6pm

• Commanders -2.5 point favourites, Over/Under 45.5 points

• Highmark Stadium, Buffalo, Sunday 6pm

• Bills -16.5 point favourites, Over/Under 47.5 points

• Ford Field, Detroit, Sunday 6pm

• Lions -9.5 point favourites, Over/Under 45.5 points

• NRG Stadium, Houston, Sunday 6pm

• Texans -7 point favourites, Over/Under 39.5 points

• Gillette Stadium, Foxborough, Sunday 6pm

• Patriots -4.5 point favourites, Over/Under 43.5 points

• MetLife Stadium, New Jersey, Sunday 6pm

• Chargers -5.5 point favourites, Over/Under 44 points

• Raymond James Stadium, Tampa, Sunday 6pm

• Eagles -3.5 point favourites, Over/Under 43.5 points

• SoFi Stadium, Los Angeles, Sunday 9.05pm

• Rams -3.5 point favourites, Over/Under 49 points

• Levi's Stadium, Santa Clara, Sunday 9.05pm

• 49ers -3.5 point favourites, Over/Under 47 points

• Arrowhead Stadium, Kansas City, Sunday 9.25pm

• Ravens -2.5 point favourites, Over/Under 48.5 points

• Allegiant Stadium, Las Vegas, Sunday 9.25pm

• Bears -1 point favourites, Over/Under 47.5 points

• AT&T Stadium, Arlington, Monday 1.20am

• Packers -7 point favourites, Over/Under 47.5 points

• Hard Rock Stadium, Miami, Tuesday 12.15am

• Dolphins -2.5 point favourites, Over/Under 45.5 points

• Mile High, Denver, Monday 1.15am

• Broncos -7.5 point favourites, Over/Under 44 points

View the latest NFL odds.

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All odds and markets are correct as of the date of publication.